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Small Molecule Chemistry
Does PACOCF3, BML-ST336 inhibit all isoforms of phospholipase A2 (PLA2)?
PACOCF3 (BML-ST336) inhibits of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM). Unfortunately, we have…
Tue, Jul 18, 2023
Why your SCREEN-WELL® Natural product library (BML-2865) supplied in mg/mL instead of mM?
When our SCREEN-WELL® Natural product library (BML-2865) library was originally developed, we included some very exotic compounds. Unlike synthetic chemicals,…
Tue, Jul 18, 2023
What are the main advantages in using your SCREEN-WELL® FDA-approved drug library (BML-2843)?
Here is the list of advantages in using our SCREEN-WELL® FDA-approved drug library (BML-2843): – Compounds supplied at 10 mM…
Tue, Jul 18, 2023
Which plates are used to package the SCREEN-WELL® compound libraries?
The SCREEN-WELL® compound libraries are packaged using deep-well 96-well plates from either Corning Costar (Prod. Ref. 3959) or Thermo Matrix…
Tue, Jul 18, 2023
Are the compounds included in your SCREEN-WELL® compound libraries patented?
Some of the compounds included are patented. Some others have a patent but it is expired. Some are covered by…
Tue, Jul 18, 2023
What is the purity of the compounds included in your SCREEN-WELL® Natural product library (BML-2865)?
Compounds in our SCREEN-WELL® Natural product library (BML-2865) are 85% pure or better (with most of the compounds coming in…
Tue, Jul 18, 2023
Can you please explain what the SCREEN-WELL® compound libraries are used for?
In general terms, a laboratory or company interested in high-throughput screening for drug discovery will have already established an assay…
Tue, Jul 18, 2023
General handling, storage instructions, and stability of the SCREEN-WELL® compound libraries
Compound libraries should be thawed at room temperature. Once thawed, the plates can be gently centrifuged to bring down any…
Tue, Jul 18, 2023
Can I customize the SCREEN-WELL® compound library I am interested in?
SCREEN-WELL® compound libraries can be customized to fit your experimental requirements (384-well plate, cherry-picking, smaller volume, etc.). Please feel free…
Tue, Jul 18, 2023
How should I dilute my SCREEN-WELL® compound library for my assay?
Each one of the compounds are supplied at a concentration of 10 mM in DMSO, unless stated otherwise. In high-throughput…
Tue, Jul 18, 2023