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Small Molecule Chemistry
Does PACOCF3, BML-ST336 inhibit all isoforms of phospholipase A2 (PLA2)?
PACOCF3 (BML-ST336) inhibits of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM). Unfortunately, we have…
Tue, Jul 18, 2023
Why your SCREEN-WELL® Natural product library (BML-2865) supplied in mg/mL instead of mM?
When our SCREEN-WELL® Natural product library (BML-2865) library was originally developed, we included some very exotic compounds. Unlike synthetic chemicals,…
Tue, Jul 18, 2023
What are the main advantages in using your SCREEN-WELL® FDA-approved drug library (BML-2843)?
Here is the list of advantages in using our SCREEN-WELL® FDA-approved drug library (BML-2843): – Compounds supplied at 10 mM…
Tue, Jul 18, 2023
Are the compounds included in your SCREEN-WELL® compound libraries patented?
Some of the compounds included are patented. Some others have a patent but it is expired. Some are covered by…
Tue, Jul 18, 2023
What is the purity of the compounds included in your SCREEN-WELL® Natural product library (BML-2865)?
Compounds in our SCREEN-WELL® Natural product library (BML-2865) are 85% pure or better (with most of the compounds coming in…
Tue, Jul 18, 2023
Can I customize the SCREEN-WELL® compound library I am interested in?
SCREEN-WELL® compound libraries can be customized to fit your experimental requirements (384-well plate, cherry-picking, smaller volume, etc.). Please feel free…
Tue, Jul 18, 2023
How should I dilute my SCREEN-WELL® compound library for my assay?
Each one of the compounds are supplied at a concentration of 10 mM in DMSO, unless stated otherwise. In high-throughput…
Tue, Jul 18, 2023
Can I have the IC50 values of the compounds included in your SCREEN-WELL® compound libraries?
Regretfully, we do not test for IC50 values. IC50 values are not always available and when they are, they apply…
Tue, Jul 18, 2023
Which software can I use to open the SD files that come with the SCREEN-WELL® compound libraries?
Structure files (or SD files) can be opened using the ISIS/BASE software. ISIS/BASE is the only program that can read…
Tue, Jul 18, 2023
How many compounds in your SCREEN-WELL® Neurotransmitter library (BML-2810) are clinically approved?
We did an overlap analysis of our SCREEN-WELL® Neurotransmitter library (BML-2810) with our SCREEN-WELL® FDA-approved drug library (BML-2843) and there…
Tue, Jul 18, 2023