Endocrine Dysfunction

Visualize Toxic Events In Vitro

Studies indicate that drugs can cause endocrine abnormalities through several mechanisms, including direct alteration of hormone production, regulation of the hormone axis, hormonal binding, transport, and signaling. Drug-induced endocrine and metabolism disorders include electrolyte and calcium abnormalities, carbohydrate metabolism, and thyroid and gonadal disorders. A critical understanding of endocrine effects can better predict drug-induced adverse effects and better choice for drug design and treatment rationale.