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Nephrotoxicity
Visualize Toxic Events In Vitro
Acute kidney injury (AKI), the precursor to Acute renal failure (ARF) is the rapid loss of the kidney’s ability to remove waste and help balance fluids and electrolytes in your body. This sudden loss of kidney function, which is recoverable, can be the result of illness, physical trauma, or nephrotoxic drugs. In contrast, chronic kidney disease (CKD) is a long and usually slow process where the kidneys lose their ability to function, and if not resolved, progresses to end-stage renal disease (ESRD). During ESRD, the kidneys are no longer able to remove sufficient waste and excess fluid from the body, requiring the need for dialysis or a kidney transplant. Numerous studies have identified a number of proteins and metabolites present in blood or urine with varied utility as diagnostic or prognostic markers of these various stages of kidney injury, disease progression, or nephrotoxicity.
Product Highlight
BioPorto® NGAL ELISA Kits
Versatile BioPorto® ELISA kits for detection of NGAL in variety of species and sample types
- Sensitive ELISAs validated for human samples and a broad range of model systems (mouse, rat, dog, pig and monkey)
- Rapid NGAL (human) assay with results in less than 1 hour
- Large range of sample types (culture supernatants, plasma, serum, tissue, and urine)
Detect NGAL Across Diverse Model Systems
Predictive Toxicology
Download ResourceKIM-1 (human) ELISA kit
ADI-900-226
Ultra sensitive (1.279 pg/ml) ELISA kit, enabling reduced input sample and matrix interference, for the quantification of KIM-1, an early biomarker for kidney injury or disease.
| Application | Colorimetric detection, ELISA |
|---|---|
| Sensitivity | 1.279 pg/ml (range 7.813 – 500 pg/ml) |
| Species Reactivity | Human |
| Application | Colorimetric detection, ELISA |
|---|---|
| Assay Time | <4 hours |
| Sensitivity | 4pg/ml (range 10-1000pg/ml) |
| Species Reactivity | Human |
SCREEN-WELL® Nephrotoxicity library
ENZ-LIB100
Essential standards for predictive toxicology screening
Detection of Acute Kidney Injury
Enzo provides a variety of tools to detect the early stages of acute kidney injury or renal failure, including sensitive ELISA kits for detection of KIM-1, NGAL (lipocalin-2), and cystatin C. These rapid, high sensitivity kits are validated for a variety of species and samples types.
KIM-1 (human) ELISA Kit
Ultra-sensitive ELISA kit, enabling reduced input sample and matrix interference, for the quantification of KIM-1, an early biomarker for acute kidney injury or disease.
- Sensitive ELISA measures as little as 1.2 pg/mL of KIM-1 in human urine
- Low cross-reactivity to TIM-3 and TIM-4
- Rapid assay with results in < 2 hours for 38 duplicate samples
- Fully quantitative results and superior throughput vs. Western blot
For research use only. Not for use in diagnostic procedures.
Rapidly Quantify KIM-1, an Early Biomarker of AKI
