Apoptosis

Of the three major established programmed cell death (PCD) pathways, Apoptosis (PCD Type 1) is the most-well characterized, being recognized as a critical regulator of development, immunity, as well as organ and tissue homeostasis. Apoptotic cells die in a controlled fashion in response to a variety of extrinsic or intrinsic signals (e.g., activation of TNF receptors, DNA damage, mitochondrial pathways). Influencing cells to undergo or resist apoptosis is the aim of countless drugs (both in use and development) for treatment of cancer, neurodegenerative, and immune-related disease. The interplay between apoptotic, autophagic, and necrotic pathways promises to yield further targets for therapeutic intervention. With over 400 products for the analysis of cell death, Enzo enables detection of phenotypic hallmarks of apoptotic cell death (see figure below), and the complete analysis of cross-talk between PCD pathways.