Home Shop CD40 (mouse) monoclonal antibody (FGK45) (preservative free)

CD40 (mouse) monoclonal antibody (FGK45) (preservative free)

ALX-805-046PF

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Widely used stimulatory MAb to CD40. Shown to indirectly activate natural killer (NK) cells, producing significant antitumor and antimetastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

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This antibody is covered by our Worry-Free Guarantee.

Product Details

Alternative Name	TNFRSF 5
Application	ELISA, Flow Cytometry, FUNC, WB
Application Notes	Functional Application: activates B and NK cells in vivo and in vitro.
Clone	FGK45
Formulation	Liquid. In sterile PBS.
Host	Rat
Immunogen	Recombinant mouse CD40 fusion protein.
Isotype	IgG2a
Purity Detail	Protein G-affinity purified.
Source	Purified from hybridoma tissue culture supernatant.
Species Reactivity	Mouse
UniProt ID	P27512
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Handling	Avoid freeze/thaw cycles.
Short Term Storage	+4°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

ATAD5 deficiency decreases B cell division and Igh recombination: K.J. Zanotti, et al.; J. Immunol. 194, 32 (2015), Abstract
CD40 amplifies Fas-mediated apoptosis: a mechanism contributing to emphysema: A. Shigeta, et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 303, L141 (2012), Abstract — Full Text
Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance: V.S. Fear, et al.; J. Immunol. 187, 4561 (2011), Abstract — Full Text
Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs): H. Yanai, et al.; PNAS 108, 11542 (2011), Abstract — Full Text
Expression of Cellular FLIP by B Cells Is Required for Their Participation in an Immune Response: F. Coffey & T. Manser; J. Immunol. 184, 4871 (2010), Abstract — Full Text
Identification and characterization of a lupus suppressor 129 locus on chromosome 3: F. Carlucci, et al.; J. Immunol. 184, 6255 (2010), Abstract — Full Text
The pleckstrin homology domain adaptor protein Bam32/DAPP1 is required for germinal center progression: T.T. Zhang, et al.; J. Immunol. 184, 164 (2010), Abstract — Full Text
A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity: W.A. Schroder, et al.; J. Immunol. 184, 2663 (2010), Abstract — Full Text
A role for cFLIP in B cell proliferation and stress MAPK regulation: H. Zhang, et al.; J. Immunol. 182, 207 (2009), Abstract — Full Text
Agonistic Anti-CD40 Antibody Profoundly Suppresses the Immune Response to Infection with Lymphocytic Choriomeningitis Virus: C. Bartholdy, et al.; J. Immunol. 178, 1662 (2007), Abstract