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Figure: Epitope Mapping of MAbs MRPr1, QCRL-1 & MRPm6. Topological model of MRPdepicting the approx. locations of the MRPr1, QCRL-1 and MRPm6 epitopes. The model shown is only one of several possible configurations. MSD=membrane spanning domain; NBD=nucleotide binding domain. From R. Hipfner, et al.; Br. J. Cancer 78,1134 (1998).
Product Details
| Alternative Name |
Multidrug resistance-associated protein 1, ABCC1 |
|---|---|
| Application |
Flow Cytometry, ICC, IHC (FS), IHC (PS), WB |
| Application Notes |
Flow Cytometry: cell permeabilization required |
| Clone |
MRPr1 |
| Crossreactivity |
Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein or human MRP2 (cMOAT) to MRP 5. |
| Formulation |
Liquid. In serum free culture supernatant containing 0.7% BSA and 0.1% sodium azide. |
| Host |
Rat |
| Immunogen |
Recombinant human MRP1 (multidrug resistance-associated protein 1) (aa 192-360). |
| Isotype |
IgG2a |
| Recommendation Dilutions/Conditions |
Suggested starting dilution is 1:20Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. |
| Species Reactivity |
Human, Mouse |
| Specificity |
Recognizes the internal epitope (G238SDLWSLNKE247) of MRP1, overexpressed in various human non-P-glycoprotein MDR tumor cell lines. |
| UniProt ID |
P33527 |
| Worry-free Guarantee |
This antibody is covered by our Worry-Free Guarantee. |
Handling & Storage
| Short Term Storage |
+4°C |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Late-stage placental barrier model for transport studies of prescription drugs during pregnancy: Kouthouridis, S., Saha, P., et al.; Lab Chip 25, 3168 (2025), Abstract
- GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators.: Hanssen, K. M., Wheatley, M. S., et al.; FEBS J. 289, 3854 (2022), Application(s): WB / Reactant(s): Human, Abstract
- A thiol-bound drug reservoir enhances APR-246-induced mutant p53 tumor cell death.: Ceder, S., Eriksson, S. E., et al.; EMBO Mol. Med. 13, e10852 (2021), Application(s): WB, Abstract
- Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy.: Chen, X., Maffucci, T., et al.; Cancers (Basel) 12, (2020), Application(s): WB, Abstract
- Pomolic acid induces apoptosis and inhibits multidrug resistance protein MRP1 and migration in glioblastoma cells: Guimarães, L. P. T. P., Rocha, G. D. G., et al.; Oncol. Rep. 38, 2525 (2017), Abstract
- A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity.: Kovacevic, Z., Richardson, D. R., et al.; J. Biol. Chem. 291, 27042 (2016), Application(s): WB / Reactant(s): Mouse, Abstract
- ABCC1 confers tissue-specific sensitivity to cortisol versus corticosterone: A rationale for safer glucocorticoid replacement therapy.: Walker, B. R., Andrew, R., et al.; Sci. Transl. Med. 8, 352ra109 (2016), Application(s): WB, Abstract
- Localization of MRP-1 to the outer mitochondrial membrane by the chaperone protein HSP90β: E. Roundhill, et al.; FASEB J. 30, 1712 (2016), Application(s): ICC-IF, WB / Reactant(s) Human, Abstract
- Characterization of efflux transport proteins of the human choroid plexus papilloma cell line HIBCPP, a functional in vitro model of the blood-cerebrospinal fluid barrier: A. Bernd, et al.; Pharm. Res. 32, 2973 (2015), Abstract
- Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.: Wang, F., Gerber, H. P., et al.; Mol. Cancer Ther. 14, 952 (2015), Application(s): WB, Abstract
- The effect of maternal obesity on the expression and functionality of placental P-glycoprotein: Implications in the individualized transplacental digoxin treatment for fetal heart failure: C. Wang, et al.; Placenta 36, 1138 (2015), Application(s): Western blot with human placenta, Abstract — Full Text
- Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen: L. Cheung, et al.; Biochem. Pharmacol. 93, 380 (2015), Application(s): Western blot with HEK293 cells, Abstract
- Inhibition of Multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme: A. Tivnan, et al.; Front. Neurosci. 9, 218 (2015), Application(s): Western Blot, Abstract — Full Text
- High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4): L. Cheung, et al.; Biochem. Pharmacol. 91, 97 (2014), Application(s): Western blot with MCF7 cells, Abstract
- Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC): Caceres, N. E., Aerts, M., et al.; PLoS One 8, e58285 (2013), Abstract
- Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells: ElAli, A., Hermann, D. M., et al.; Brain Pathol. 22, 175 (2012), Abstract
- Inflammatory regulation of ATP binding cassette efflux transporter expression and function in microglia: C.J. Gibson, et al.; J. Pharmacol. Exp. Ther. 343, 650 (2012), Application(s): Western blot with BV-2 cells, Abstract — Full Text
- Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function: L. Qin, et al.; Drug. Metab. Dispos. 40, 1403 (2012), Application(s): Immunofluorescence using HEK293 cells, Abstract
- Resistance to paclitaxel in a cisplatin-resistant ovarian cancer cell line is mediated by P-glycoprotein.: Clynes, M., Stordal, B., et al.; PLoS One 7, e40717 (2012), Reactant(s): Human, Abstract
- ABCC multidrug transporters in childhood neuroblastoma: clinical and biological effects independent of cytotoxic drug efflux: Henderson, M. J., Haber, M., et al.; J. Natl. Cancer Inst. 103, 1236 (2011), Abstract
- Direct and coordinate regulation of ATP-binding cassette transporter genes by Myc factors generates specific transcription signatures that significantly affect the chemoresistance phenotype of cancer cells: Porro, A., Haber, M., et al.; J. Biol. Chem. 285, 19532 (2010), Abstract
- Effluxing ABC transporters in human corneal epithelium.: Vellonen, K. S., Mannermaa, E., et al.; J. Pharm. Sci. 99, 1087 (2010), Application(s): IHC-IF, WB / Reactant(s): Human, Abstract
- Human skeletal muscle drug transporters determine local exposure and toxicity of statins: Knauer, M. J., Urquhart, B. L., et al.; Circ. Res. 106, 297 (2010), Abstract
- P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas: Ginguené, C., Champier, J., et al.; Brain Pathol. 20, 926 (2010), Abstract
- ABCC1: a gateway for pharmacological compounds to the ischaemic brain.: Kilic, E., Kilic, U., et al.; Brain 131, 2679 (2008), Application(s): WB / Reactant(s): Mouse, Abstract
- Identification and characterization of functionally important elements in the multidrug resistance protein 1 COOH-terminal region: C.J. Westlake, et al.; J. Biol. Chem. 279, 53571 (2004), Abstract — Full Text
- Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required: Leslie, E. M., Haimeur, A., et al.; J. Biol. Chem. 279, 32700 (2004), Abstract
- A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin.: Glynn, S. A., Gammell, P., et al.; Br. J. Cancer 91, 1800 (2004), Application(s): WB / Reactant(s): Human, Abstract
- Functional importance of polar and charged amino acid residues in transmembrane helix 14 of multidrug resistance protein 1 (MRP1/ABCC1): identification of an aspartate residue critical for conversion from a high to low affinity substrate binding state: Zhang, D. W., Gu, H. M., et al.; J. Biol. Chem. 278, 46052 (2003), Abstract
- The multidrug resistance protein 1: a functionally important activation marker for murine Th1 cells: S. Prechtl, et al.; J. Immunol. 164, 754 (2000), Abstract — Full Text
- Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies: G.L. Scheffer, et al.; Cancer Res. 60, 5269 (2000), Abstract — Full Text
- Rhodamine 123 binds to multiple sites in the multidrug resistance protein (MRP1): R. Daoud, et al.; Biochemistry 39, 15344 (2000), Abstract
- The multidrug resistance protein is photoaffinity labeled by a quinoline-based drug at multiple sites: R. Daoud, et al.; Biochemistry 39, 6094 (2000), Abstract
- Bcl-2, bax and bcl-xL expression in human sensitive and resistant leukemia cell lines: V. Nuessler, et al.; Leukemia 13, 1864 (1999), Abstract
- Reproducible flow cytometric methodology for measuring multidrug resistance in leukaemic blasts: M. Pallis, et al.; Adv. Exp. Med. Biol. 457, 77 (1999), Abstract
- Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier: V.V. Rao, et al.; PNAS 96, 3900 (1999), Abstract — Full Text
- Increased expression of multidrug resistance related proteins Pgp, MRP1, and LRP/MVP occurs early in colorectal carcinogenesis: G.A. Meijer, et al.; J. Clin. Pathol. 52, 450 (1999), Abstract
- Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma: H.J. Arts, et al.; Clin. Cancer Res. 5, 2798 (1999), Abstract — Full Text
- Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP): D.R. Hipfner, et al.; Br. J. Cancer 78, 1134 (1998), Abstract
- Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia: M.L. Den Boer, et al.; Blood 91, 2092 (1998), Abstract — Full Text
- The prognostic significance of expression of the multidrug resistance-associated protein (MRP) in primary breast cancer: K. Nooter, et al.; Br. J. Cancer 76, 486 (1997), Abstract
- Optimal immunocytochemical and flow cytometric detection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia: M.L. Den Boer, et al.; Leukemia 11, 1078 (1997), Abstract
- Tissue distribution of the multidrug resistance protein: M.J. Flens, et al.; Am. J. Pathol. 148, 1237 (1996), Abstract
- Multidrug resistance-associated protein expression in clinical gastric carcinoma: K. Endo, et al.; Cancer 77, 1681 (1996), Abstract
- Methods to detect P-glycoprotein-associated multidrug resistance in patients’ tumors: consensus recommendations: W.T. Beck, et al.; Cancer Res. 56, 3010 (1996), Abstract
- Expression of the multidrug resistance-associated protein (MRP) gene in primary non-small-cell lung cancer: K. Nooter, et al.; Ann. Oncol. 7, 75 (1996), Abstract
- Membrane transport proteins associated with drug resistance expressed in human melanoma: D. Schadendorf, et al.; Am. J. Pathol. 147, 1545 (1995), Abstract
- Expression of the multidrug resistance-associated protein (MRP) gene in human cancers: K. Nooter, et al.; Clin. Cancer Res. 1, 1301 (1995), Abstract
- Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies: D.R. Hipfner, et al.; Cancer Res. 54, 5788 (1994), Abstract
- The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump: G.J. Zaman, et al.; PNAS 91, 8822 (1994), Abstract — Full Text
- Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies: M.J. Flens, et al.; Cancer Res. 54, 4557 (1994), Abstract
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