HDAC1 inhibitor
Inhibitor of histone deacetylase 1 (HDAC1) (IC50 = 4.5µM) and maize histone deacetylase HD2 (IC50=1.9µM).
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Product Details
| Alternative Name |
3-(4-Toluoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide |
|---|---|
| Appearance |
Off-white powder. |
| Couple Target |
HDAC, HDAC1, HDAC2 |
| Couple Type |
Inhibitor |
| Formula |
C16H16N2O3 |
| Identity |
Determined by 1H-NMR. |
| MW |
284.3 |
| Purity |
≥95% (HPLC) |
| Solubility |
Soluble in DMSO. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Handling |
Protect from light. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- The Distinct Roles of Class I and II RPD3-Like Histone Deacetylases in Salinity Stress Response: Ueda, M., Matsui, A., et al.; Plant Physiol. 175, 1760 (2017), Abstract
- Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation: A. Mai, et al.; J. Med. Chem. 45, 1778 (2002), Abstract
- 3-(4-aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a new class of synthetic histone deacetylase inhibitors: S. Massa, et al.; J. Med. Chem. 44, 2069 (2001), Abstract
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|---|---|
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Last modified: May 29, 2024
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