Amastatin . hydrochloride

ALX-260-003

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Aminopeptidase inhibitor

Competitive inhibitor of human serum aminopeptidase A, pig kidney leucine aminopeptidase, leucine aminopeptidase, tyrosine aminopeptidase, but not of aminopeptidase B. Has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases.

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Product Details

Alternative Name	[(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
Appearance	White to off-white powder.
CAS	100938-10-1
Formula	C₂₁H₃₈N₄O₈. HCl
MW	474.6 . 36.5
Purity	≥98% (HPLC)
Solubility	Soluble in acetic acid.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Administration of Alphitobius diaperinus or Tenebrio molitor before meals transiently increases food intake through enterohormone regulation in female rats: A.M. Gómez, et al.; J. Sci. Food Agric. 103, 1660 (2023), Abstract
NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake: E. Alari-Pahissa, et al.; PLoS Pathog. 17, e1009868 (2021), Abstract
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem. 27, 417 (1984), Abstract
Structure and Chemical Synthesis of Amastatin: H. Tobe, et al.; Agric. Biol. Chem. 43, 591 (1979)
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes: T. Aoyagi, et al.; J. Antibiot. (Tokyo) 31, 636 (1978), Abstract

Last modified: May 29, 2024

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Amastatin . hydrochloride

ALX-260-003

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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