ZytoMation® BCL6 Dual Color Break Apart FISH Probe

The ZytoMation^® BCL6 Dual Color Break Apart FISH Probe is designed to detect translocations involving the chromosomal region 3q27.3 harboring the BCL6 gene. Translocations involving the BCL6 gene are commonly identified in B-cell lymphomas. The most common rearrangement is the translocation t(3;14)(q27;q32.3) resulting in BLC6-IGH gene fusion. In DLBCL, the most common histologic subtype of NHL, BCL6 translocations represent one of the most frequent cytogenetic abnormality, occurring in 20% to 40% of the cases.