ZytoMation® ALK Dual Color Break Apart FISH Probe

The ZytoMation^® ALK Dual Color Break Apart FISH Probe is designed to detect rearrangements involving the chromosomal region 2p23.1-p23.2 harboring the ALK gene. ALK encodes a transmembrane receptor tyrosine kinase. This gene exerts characteristic oncogenic activities through fusion to several gene partners or mutations both in hematopoietic and non-hematopoietic solid tumors. Translocations affecting the ALK gene locus are frequently found in ALCL.