ZytoLight® SPEC YWHAE Dual Color Break Apart Probe

The ZytoLight ® SPEC YWHAE Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region 17p13.3 harboring the YWHAE gene. Altered expression of 14-3-3 family proteins is associated with development and progression of cancer. The fusion between YWHAE and one of the FAM22 family members (FAM22A or FAM22B) caused by a t(10;17)(q22;p13) has been identified in the clinically aggressive, high-grade endometrial stromal sarcoma (ESS) as well as in clear cell sarcoma of the kidney (CCSK).