ZytoLight® SPEC VHL/CEN 3 Dual Color Probe

The ZytoLight ® SPEC VHL/CEN 3 Dual Color Probe is designed for the detection of deletions affecting the VHL gene. Loss of heterozygosity at chromosome 3p and inactivation of the VHL gene by deletion or mutation is the most frequent genetic change in sporadic as well as VHL disease-associated conventional renal cell carcinomas (RCC) whereas alterations of this region are rarely seen in papillary and chromophobe RCC.