ZytoLight® SPEC NUTM1 Dual Color Break Apart Probe

The ZytoLight ® SPEC NUTM1 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 15q14 harboring the NUTM1 gene. NUT midline carcinoma (NMC) is a rare and aggressive form of squamous cell carcinoma that arises mainly in the head, neck, or mediastinum. NMCs may be indistinguishable from more common squamous cell carcinomas and are thus an underdiagnosed entity. Therefore, the diagnosis of NMC depends on the confirmation of NUTM1 rearrangement.