ZytoLight® SPEC NR4A3 Dual Color Break Apart Probe

The ZytoLight ® SPEC NR4A3 Dual Color Break Apart Probe is designed to detect translocations involving the chromosomal region 9q22.33-q31.1. The most frequent reciprocal translocation is t(9;22)(q22.3-q31;q12.2) found in about 70% of EMC generating a EWSR1-NR4A3 fusion gene in which the 3’-terminal part of EWSR1 is replaced by the entire NR4A3 gene. EMC is histologically characterized by a mixture of cellular and myxoid stromal components, making it difficult to distinguish it from other benign or malignant mesenchymal tumors.