ZytoLight® SPEC IGL Dual Color Break Apart Probe

The ZytoLight ® SPEC IGL Dual Color Break Apart Probe is designed to detect rearrangements affecting the chromosomal region 22q11.22 harboring the IGL gene cluster region. The majority of translocations involve the immunoglobulin heavy chain (IGH) locus while a minor part involves the immunoglobulin light chain loci, either the kappa light chain (IGK) or the lambda light chain (IGL). IGK and IGL rearrangements resulting from the variant translocations t(2;8)(p12;q24.21) and t(8;22)(q24.21;q11.2), respectively, have been detected in up to 25% of Burkitt’s Lymphoma cases.