ZytoLight® SPEC EML4 Dual Color Break Apart Probe

The ZytoLight ® SPEC EML4 Dual Color Break Apart Probe is designed to detect rearrangements involving the chromosomal region 2p21 harboring the EML4 gene. Inversions in the short arm of chromosome 2 [inv(2)(p21p23)] have been frequently detected in non-small cell lung cancer and lead to the formation of EML4-ALK fusion transcripts. A few reports also identified these fusion transcripts in breast, gastric, and colorectal cancers.