ZytoLight® SPEC CCND1/IGH Dual Color Dual Fusion Probe

The ZytoLight ® SPEC CCND1/IGH Dual Color Dual Fusion Probe is designed to detect translocation t(11;14)(q13.3;q32.3) frequently found in mantle cell lymphomas. The translocation t(11;14)(q13.3;q32.3) that involves the CCND1 and IGH gene regions is detected in up to 95% of patients with mantle cell lymphomas. However, the t(11;14) has also been identified in other lymphoproliferative disorders, such as B-prolymphocytic leukemia, and in plasma cell myelomas, B-cell chronic lymphocytic leukemia, and in splenic lymphomas with villous lymphocytes.