ZytoLight® SPEC ALK/2q11 Dual Color Probe

The ZytoLight ® SPEC ALK/2q11 Dual Color Probe is designed for detection of amplifications of the chromosomal region harboring the ALK gene. In addition to ALK gene fusions, ALK has also shown to be amplified and show copy number gains in a variety of tumors including non-small cell lung cancer and alveolar rhabdomyosarcoma. In colorectal cancer, ALK amplification was correlated with nodal status suggesting that ALK amplified tumors are also a frequent genetic event in the tumorigenesis of neuroblastomas and were found to result in high ALK expression correlating with an unfavorable neuroblastoma phenotype.