ZytoDot® 2C SPEC CDKN2A/CEN 9 Probe

The ZytoDot ® 2C SPEC CDKN2A/CEN 9 Probe is designed for the detection of CDKN2A deletions frequently observed in most tumor cell lines as well as in primary human malignancies. CDKN2A has been identified as a major susceptibility gene for melanoma. The tumor suppressor gene CDKN2A is inactivated by homozygous deletions with high frequency in a variety of human primary tumors e.g. bladder and renal cell carcinoma, non-small cell lung cancer, sarcoma, glioma and mesothelioma. Deletion of the CDKN2A gene is found in up to 80% of T-cell acute lymphoblastic leukemia cases.