ZytoDot® 2C SPEC ALK Break Apart Probe (Digoxigenin/DNP)

The ZytoDot ® 2C SPEC ALK Break Apart Probe is designed to detect rearrangements involving the ALK gene. ALK translocations are frequently found in anaplastic large cell lymphoma (ALCL), an aggressive non-Hodgkin lymphoma. Additionally, inversions [inv(2)(p21p23)] affecting the ALK gene have been frequently detected in non-small cell lung cancer (NSCLC) and lead to the formation of EML4-ALK fusion transcripts. ALK kinase targeted therapies may represent a very effective therapeutic strategy in NSCLC patients carrying EML4-ALK rearrangements.