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ZSTK474

ALX-270-454

4 citations

  • ALX-270-454-M010   —   10 mg
    $149.00

Cell permeable, reversible, potent and specific inhibitor of phosphoinositide 3-kinase (IC50=17nM for PI(3)K p110β, IC50=53nM for PI(3)K p110γ and IC50=6nM for PI(3)K p110δ). Blocks cellular PI(3)K/Akt (PKB) signalling in vitro and inhibits Akt(PKB)-dependent tumor growth in mice in vivo without significant toxic effect. More effective than LY 294,002 (Prod. No. BML-ST420) in vitro and as in vivo.

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Regulatory Status

RUO – Research Use Only