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Potent and specific inhibitor of the protein kinase c-Raf (IC50=70nM). Has no significant effect on many other protein kinases tested (even at 50µM) with the exception of p38 (SAPK2a) (IC50=2µM) and SAPK2b (p38β) (IC50=2µM). Induces a paradoxical >100-fold activation of c-Raf in whole cells.
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| Regulatory Status |
RUO – Research Use Only |
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