ZM-323881

BML-EI385

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VEGFR inhibitor

Potent and selective inhibitor of the kinase activity of the human vascular endothelial growth factor receptor 2 (VEGFR2/KDR). Selectively inhibits VEGFR2 over VEGFR1 and other receptor tyrosine kinases with an IC₅₀ = 2nM. Useful tool for exploring the biology of VEGFR receptors.

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Product Details

Alternative Name	5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methyl phenol
Appearance	White to off-white solid.
CAS	193001-14-8
Couple Target	VEGFR
Couple Type	Inhibitor
Formula	C₂₂H₁₈FN₃O₂
MW	375.4
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (3 mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for 1 year as supplied. Stock solutions can be stored at -20°C for up to 3 months.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity , probably through VEGF receptor 1 in vivo.: C.A. Glass, et al.; J. Physiol. 572, 243 (2006), Abstract
Selective inhibition of vascular endothelial growth factor receptor-2 (VEGFR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF: A. Endo, et al.; J. Recept. Signal Transduct. Res. 23, 239 (2003), Abstract
ZM323881, a novel inhibitor of vascular endothelial growth factor-receptor-2 tyrosine kinase activity: C.E. Whittles, et al.; Microcirculation 9, 513 (2002), Abstract

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ZM-323881

BML-EI385

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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