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Zinc(II) Protoporphyrin IX

ALX-430-049

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Heme oxygenase inhibitor

Potent and selective inhibitor of heme oxygenase (K_i=3nM), the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC₅₀=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier. An useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter.

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Product Details

Appearance	Dark solid.
CAS	15442-64-5
Couple Target	Heme oxygenase
Couple Type	Inhibitor
Formula	C₃₄H₃₂N₄O₄Zn
Identity	Identity determined by UV and NMR.
MW	626.0
Purity	≥95% (TLC)
Solubility	Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 3 years after receipt when stored at -20°C. Make solutions fresh daily. Product may be unstable in solution if exposed to light.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The Antimalarial Drug Artesunate Mediates Selective Cytotoxicity by Upregulating HO-1 in Melanoma Cells: F. Jochims, et al.; Biomedicines 11, 2393 (2023), Abstract
Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells: Fernández-Acosta, R., Hassannia, B., et al.; Cells 12, (2023), Abstract
Novel Iron Oxide Nanoparticles Induce Ferroptosis in a Panel of Cancer Cell Lines: Fernández-Acosta, R., Iriarte-Mesa, C., et al.; Molecules 27, (2022), Abstract
Heme oxygenase-1 in the spinal cord plays crucial roles in the analgesic effects of pregabalin and gabapentin in a spared nerve-injury mouse model: K. Godai, et al.; Neurosci. Lett. 767, 136310 (2022), Abstract
5-Aminolevulinic acid exerts renoprotective effect via Nrf2 activation in murine rhabdomyolysis-induced acute kidney injury: A. Uchida, et al.; Nephrology (Carlton) 24, 28 (2019), Application(s): Treatment of mice, Abstract
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma: Hassannia, B., Wiernicki, B., et al.; J. Clin. Invest. 128, 3341 (2018), Abstract
The apolipoprotein A-I mimetic peptide, D-4F, restrains neointimal formation through heme oxygenase-1 up-regulation: Liu, D., Wu, M., et al.; J. Cell. Mol. Med. 21, 3810 (2017), Abstract
The apolipoprotein A-I mimetic peptide, D-4F, alleviates ox-LDL-induced oxidative stress and promotes endothelial repair through the eNOS/HO-1 pathway: D. Liu, et al.; J. Mol. Cell. Cardiol. 105, 77 (2017), Abstract
Expression of the thioredoxin system in an in vivo-like cancer cell environment upon auranofin treatment: M. Bhatia, et al.; Eur. J. Cell Biol. 95, 378 (2016), Application(s): Evaluation of auranofin induced cytotoxicity, Abstract
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways: C. Zhang, et al.; Redox Biol. 11, 1 (2016), Abstract — Full Text

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Zinc(II) Protoporphyrin IX

ALX-430-049

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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