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Zebularine

BML-GR344

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Dnmt inhibitor

Zebularine is a DNA methylation inhibitor which acts by forming a covalent complex with DNMT. It displays antiangiogenic activity and markedly inhibits vessel formation in different tumor models. It reactivates silenced E-cadherin and potentiates the effects of other epigenetic therapeutics such as vorinistat. Induces differentiation of mesenchymal cells into cardiomyocytes. Inhibits cytidine deaminase.

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Product Details

Alternative Name	1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
Appearance	Off-white solid.
Application Notes	Can be used for in vitro or cell based studies.
CAS	3690-10-6
Couple Target	Dnmt
Couple Type	Inhibitor
Formula	C₉H₁₂N₂O₅
MW	228.2
Purity	≥98% (TLC)
Solubility	Soluble in water (>25 mg/ml) or DMSO (>25 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli: D.C. Marciano, et al.; Nat. Commun. 13, 3189 (2022), Abstract
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells: M. Billam, et al.; Breast Cancer Res. Treat. Inst. 120, 581 (2010), Abstract
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt’s lymphoma Akata cells: S.P. Rao, et al.; Mol. Cancer 6, 3 (2007), Abstract
Angiostatic activity of DNA methyltransferase inhibitors: D.M.E.I. Hellebrekers, et al.; Mol. Cancer Ther. 5, 467 (2006), Abstract
Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases: L. Zhou, et al.; J. Mol. Biol. 321, 591 (2002), Abstract

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Zebularine

BML-GR344

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