Zebrafish AhR Reporter Assay System

INDIGO’s Zebrafish Aryl Hydrocarbon Receptor (zfAhR) Reporter Cells are constructed in zebrafish ZF4 cells, a cell line derived from Brachydanio rerio embryos. This zebrafish cell line has been modified to contain the luciferase reporter gene functionally linked to tandem DRE/XRE genetic response elements and a minimal promoter sequence. The principal application of this assay is in the screening of test samples to quantify any functional activity, either agonist or antagonist, that they may exert against the native zebrafish AhR.