Home Shop Z-YVAD-FMK (Ready-to-Use)

Z-YVAD-FMK (Ready-to-Use)

ALX-260-154

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Inhibitor of caspase-1 and -4

Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.

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Product Details

Alternative Name	Caspase-1 inhibitor (fluoromethylketone)
Formulation	Liquid. In DMSO.
MW	630.7
Purity	≥99% (HPLC)
Sequence	Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
Source	Synthetic.
Technical Info / Product Notes	We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress: M.B. Wachte, et al.; Life Sci. Alliance 6, e202201494 (2023), Abstract
TH17 cells promote CNS inflammation by sensing danger signals via Mincle: Zhang, Q., Liu, W., et al.; Nat. Commun. 13, 2406 (2022), Reactant(s): Mouse, Abstract
Inflammasome-Driven Interleukin-1α andInterleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity: X. Jiang, et al.; JACC Basic Transl. Sci. 4, 304 (2019), Abstract — Full Text
A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice: Quach, C., Song, Y., et al.; Nat. Commun. 10, 5681 (2019), Abstract
Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages: Guo, H., Liu, H., et al.; Aging (Albany NY) 11, 11659 (2019), Reactant(s): Mouse, Abstract
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR: Deng, M., Guo, H., et al.; J. Exp. Med. 216, 2838 (2019), Abstract
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation: C. Zhang, et al.; J. Clin. Invest. 128, 5399 (2018), Abstract — Full Text
Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol. 8, 1238 (2017), Abstract — Full Text
Rickettsia australis Activates Inflammasome in Human and Murine Macrophages: C. Smalley, et al.; PLoS One 11, e0157231 (2016), Application(s): Caspase-1 inhibition, Abstract — Full Text
T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis: Martin, B. N., Wang, C., et al.; Nat. Immunol. 17, 583 (2016), Reactant(s): Mouse, Abstract

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