Inhibitor of caspase-1 and -4
Irreversible, cell permeable inhibitor of caspase-1. Inhibits also caspase-4.
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Product Details
Alternative Name |
Caspase-1 inhibitor (fluoromethylketone) |
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Formulation |
Liquid. In DMSO. |
MW |
630.7 |
Purity |
≥99% (HPLC) |
Sequence |
Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone |
Source |
Synthetic. |
Technical Info / Product Notes |
We recommend a final concentration of 2-10µM for inhibiting caspase-1 activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. |
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Long Term Storage |
-20°C |
Shipping |
Blue Ice |
Regulatory Status |
RUO – Research Use Only |
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- Inflammasome-independent NLRP3 function enforces ATM activity in response to genotoxic stress: M.B. Wachte, et al.; Life Sci. Alliance 6, e202201494 (2023), Abstract
- TH17 cells promote CNS inflammation by sensing danger signals via Mincle: Zhang, Q., Liu, W., et al.; Nat. Commun. 13, 2406 (2022), Reactant(s): Mouse, Abstract
- Inflammasome-Driven Interleukin-1α andInterleukin-1β Production in Atherosclerotic Plaques Relates to Hyperlipidemia and Plaque Complexity: X. Jiang, et al.; JACC Basic Transl. Sci. 4, 304 (2019), Abstract — Full Text
- A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice: Quach, C., Song, Y., et al.; Nat. Commun. 10, 5681 (2019), Abstract
- Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages: Guo, H., Liu, H., et al.; Aging (Albany NY) 11, 11659 (2019), Reactant(s): Mouse, Abstract
- Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR: Deng, M., Guo, H., et al.; J. Exp. Med. 216, 2838 (2019), Abstract
- TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation: C. Zhang, et al.; J. Clin. Invest. 128, 5399 (2018), Abstract — Full Text
- Interaction and Mutual Activation of Different Innate Immune Cells Is Necessary to Kill and Clear Hepatitis C Virus-Infected Cells: V. Klöss, et al.; Front. Immunol. 8, 1238 (2017), Abstract — Full Text
- Rickettsia australis Activates Inflammasome in Human and Murine Macrophages: C. Smalley, et al.; PLoS One 11, e0157231 (2016), Application(s): Caspase-1 inhibition, Abstract — Full Text
- T cell-intrinsic ASC critically promotes T(H)17-mediated experimental autoimmune encephalomyelitis: Martin, B. N., Wang, C., et al.; Nat. Immunol. 17, 583 (2016), Reactant(s): Mouse, Abstract
- The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction: L. Mortimer, et al.; PLoS Pathog. 11, e1004887 (2015), Abstract — Full Text
- Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile: C. A. Cowardin, et al.; MBio. 6, e02386-14 (2015), Application(s): Cell Culture, Abstract — Full Text
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Last modified: May 29, 2024
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