Z-VVR-AMC

BML-P199

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Substrate for cathepsin S and cathepsin L

Sensitive fluorogenic substrate for cathepsin S and cathepsin L. Also cleaved by cathepsin B, cathepsin V, kallikrein 8, and factor VIIa/TF but not cathepsin K nor kallikrein 2. Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

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Product Details

Alternative Name	Cathepsin S & L substrate (fluorogenic)
Appearance	Lyophilized solid.
CAS	124485-41-2
MW	663.8
Purity	≥99% (TLC)
Sequence	Z-Val-Val-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
Solubility	Soluble in DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Rational design of humanized antibody inhibitors for cathepsin S: P.W. Yu, et al.; Arch. Biochem. Biophys. 751, 109849 (2024), Abstract
Efficacy of a cysteine protease inhibitor compared with enalapril in murine heart failure models: Aluja, D., Delgado-Tomás, S., et al.; iScience 27, 110935 (2024), Abstract
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress: H. Kristen, et al.; Neurobiol. Aging 68, 5 (2018), Abstract
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L.(Coleoptera: Curculionidae): S. Ben-Mahmoud, et al.; J. Insect Physiol. 72, 1 (2015), Abstract
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract
Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells: P. Xu, et al.; J. Ocul. Pharmacol. Ther. 30, 246 (2014), Abstract — Full Text
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract — Full Text

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Z-VVR-AMC

BML-P199

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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