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Z-VRPR-FMK

ALX-260-166

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MALT1 inhibitor

The proteolytic activity of the paracaspase MALT1 is key to NF-κB and T cell activation. Z-VRPR-FMK is a selective MALT1 inhibitor of such proteolytic activity.

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Product Details

Alternative Name	Z-Val-Arg-Pro-DL-Arg-FMK, MALT1 inhibitor
Appearance	White to slightly yellow powder.
Formula	C₃₁H₄₉FN₁₀O₆
MW	676.8
Purity	≥90% (HPLC)
Sequence	Z-Val-Arg-Pro-DL-Arg-fluoromethylketone . TFA
Solubility	Soluble in water (1mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Hygroscopic. Avoid freeze/thaw cycles.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells: H. Yin, et al.; Cell. Mol. Life Sci. 112, 709 (2022), Abstract
Impaired phagocytosis directs human monocyte activation in response to fungal derived β-glucan particles: G. Camilli, et al.; Eur. J. Immunol. 48, 757 (2018), Abstract — Full Text
MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression: D. Pan, et al.; Oncogene 35, 919 (2016), Application(s): Cell Culture, Abstract
MALT 1 Protease Activity Is Required for Innate and Adaptive Immune Responses: J.W. Yu, et al.; PLoS One 10, e0127083 (2015), Abstract — Full Text
The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling: T. Klein, et al.; Nat. Commun. 6, 8777 (2015), Application(s): Primary hematopoietic cell culture, Abstract — Full Text
Coregulation and modulation of NFκB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation: N. Fernandez-Jimenez, et al.; Hum. Mol. Genet. 23, 1298 (2014), Application(s): Assay / Reactant(s): Human, Abstract — Full Text
Essential Role of the Linear Ubiquitin Chain Assembly Complex in Lymphoma Revealed by Rare Germline Polymorphisms: Y. Yang, et al.; Cancer Discov. 4, 480 (2014), Abstract — Full Text
Measurement of Endogenous MALT1 Activity: D. Nagel, et al.; Bio-protocol 3, 1 (2013), Full Text
Mechanism and specificity of the human paracaspase MALT1: J. Hachmann, et al.; Biochem. J. 443, 287 (2012), Application(s): Titration, Abstract — Full Text
The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008), Abstract

Last modified: May 29, 2024

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Z-VRPR-FMK

ALX-260-166

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Handling & Storage

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