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Z-VAD(OMe)-FMK

BML-P416

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Caspase inhibitor

Irreversible and cell permeable broad-spectrum caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP.1 cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine). For cell free assays use Prod. No. ALX-260-020.

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Product Details

Alternative Name	Caspase family inhibitor (fluoromethylketone)
Appearance	White to off-white solid.
Application Notes	Irreversible, cell permeable, broad spectrum caspase inhibitor. Limited Fas-induced mouse liver damage and apoptosis to <1%, at a dose of 50µmol/kg. At 50µM, abrogated 7-hydroxystaurosporine and etoposide-induced apoptosis in HL60 cells.
CAS	187389-52-2
Formula	C₂₂H₃₀N₃O₇F
MW	467.5
Purity	≥95%
Sequence	Z-Val-Ala-Asp(OMe)-fluoromethylketone
Solubility	Soluble in DMSO (>10mg/ml), dimethyl formamide (7mg/ml) or 100% ethanol (1.3mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be divided into aliquots and stored at -20°C for up to 1 month.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion: S. Wang, et al.; PLoS Pathog. 18, e1010415 (2022), Abstract
Differential impact of doxorubicin dose on cell death and autophagy pathways during acute cardiotoxicity: Kawalec, P., Martens, M. D., et al.; Toxicol. Appl. Pharmacol. 453, 116210 (2022), Abstract
The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases: M. D. C. Conde-Rubio, et al.; Cell Death Discov. 7, 164 (2021), Abstract
An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions: Oliver Metzig, M., Tang, Y., et al.; Mol. Syst. Biol. 16, e9677 (2020), Abstract
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation: Mitchell, S., Roy, K., et al.; PNAS 115, E2888 (2018), Reactant(s): Mouse, Abstract
The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2017), Abstract — Full Text
ENCoRE: an efficient software for CRISPR screens identifies new players in extrinsic apoptosis: Trümbach, D., Pfeiffer, S., et al.; BMC Genomics 18, 905 (2017), Abstract
Chebulinic Acid Isolated From the Fruits of Terminalia chebula Specifically Induces Apoptosis in Acute Myeloid Leukemia Cells: Chhabra, S., Mishra, T., et al.; Phytother. Res. 31, 1849 (2017), Abstract
Digitoxin enhances the growth inhibitory effects of thapsigargin and simvastatin on ER negative human breast cancer cells: L.S. Einbond, et al.; Fitoterapia 109, 146 (2015), Application(s): Cell culture, Abstract
Wavelength-dependent backscattering measurements for quantitative monitoring of apoptosis, part 1: early and late spectral changes are indicative of the presence of apoptosis in cell cultures: Mulvey, C. S., Zhang, K., et al.; J. Biomed. Opt. 16, 117001 (2011), Abstract

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Z-VAD-FMK

ALX-260-020

Pan-Caspase Inhibitor. Z-VAD-FMK acts as an effective irreversible caspase inhibitor with no cytotoxic effects and, therefore, is a useful tool for studying caspase activity.

162 citations

Purity	≥95% (HPLC)

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Z-VAD(OMe)-FMK

BML-P416

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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