Z-RR-pNA

BML-P138

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Cathepsin substrate

Chromogenic substrate specific for cathepsin B. Release of pNA in monitored at 405-410 nm. This substrate is useful for inhibitor screening and kinetic analysis. Also available: calibration standard pNA (BML-KI145).

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Product Details

Alternative Name	Z-Arg-Arg-pNA
CAS	201807-90-1
Formula	C₂₆H₃₆N₁₀O₆ . 2HCl
MW	657.6
Purity	≥99%
Sequence	Z-Arg-Arg-pNA . 2HCl [Z=Cbz=Benzyloxycarbonyl; pNA=p-nitroanilide]

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs: J. Breidenbach, et al.; J. Med. Chem. 67, 8757 (2024), Abstract
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract

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Z-RR-pNA

BML-P138

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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