Z-RR-AMC

BML-P137

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Cathepsin substrate

Fluorogenic substrate specific for cathepsin B (k_cat/K_m=10⁵ M^-1s^-1). The following proteases do not cleave, or inefficiently cleave, this substrate: papain, cathepsins C/DPP-I, F, H, K/O2, L, L2/V, O, S, X/Z. Ex.: 365 nm, Em.: 440 nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for analysis of cathepsin B activity in cell extracts, inhibitor screening, and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

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Product Details

Alternative Name	Z-Arg-Arg-AMC
CAS	88937-61-5
MW	621.7
Purity	≥98%
Sequence	Z-Arg-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Late-onset Krabbe disease presenting as spastic paraplegia – implications of GCase and CTSB/D: Mächtel, R., Dobert, J. P., et al.; Ann. Clin. Transl. Neurol. 11, 1715 (2024), Abstract
Characterization of heart disease in mucopolysaccharidosis type II mice: A.M.V. Tavares, et al.; Cardiovasc. Pathol. 67, 107575 (2023), Abstract
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis: A. Di Spiezio, et al.; Biochim. Biophys. Acta Mol. Basis Dis. 1867, 166205 (2021), Abstract
Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified α-Synuclein Degradation Properties: Bunk, J., Prieto Huarcaya, S., et al.; Front Cell Dev Biol 9, 581805 (2021), Abstract
The lysosome system is severely impaired in a cellular model of neurodegeneration induced by HSV-1 and oxidative stress: H. Kristen, et al.; Neurobiol. Aging 68, 5 (2018), Abstract
Riccardin D-N induces lysosomal membrane permeabilization by inhibiting acid sphingomyelinase and interfering with sphingomyelin metabolism in vivo: L. Li, et al.; Toxicol. Appl. Pharmacol. 310, 175 (2016), Abstract
BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts: M. Tatti, et al.; Hum. Mol. Genet. 24, 4198 (2015), Abstract
Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex: C. Hiebel, et al.; J. Neurochem. 131, 484 (2014), Abstract
Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells: P. Xu, et al.; J. Ocul. Pharmacol. Ther. 30, 246 (2014), Abstract — Full Text
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract — Full Text

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Z-RR-AMC

BML-P137

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