Home Shop Z-Phe-Arg-pNA . hydrochloride

Z-Phe-Arg-pNA . hydrochloride

ALX-260-130

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Cathepsin substrate

Chromogenic substrate for Cathepsins B, K, L, and S, papain, trypsin, and plasma kallikrein. This substrate is likely to be cleaved by other cathepsins (see Z-Phe-Arg-AMC). Release of pNA is monitored at 405-410 nm (pNA ε410=8800 M^-1cm^-1). Useful for inhibitor screening and kinetic analysis.

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Product Details

Alternative Name	Z-FR-pNA . HCl
Appearance	White to off-white powder.
CAS	59188-54-4
Formula	C₂₉H₃₃N₇O₆. HCl
Formulation	Lyophilized
MW	575.6 . 36.5
Purity	≥99% (TLC)
Sequence	Z-Phe-Arg-pNA (pNA=p-Nitroanilide)
Solubility	Soluble in methanol (50mg/ml) and DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs: J. Breidenbach, et al.; J. Med. Chem. 67, 8757 (2024), Abstract
Papain expression in the Escherichia coli cytoplasm by T7-promoter engineering and co-expression with human protein disulfide isomerase (PDI) and thiol peroxidase (GPx7) genes: M.A. Hoque, et al.; Appl. Environ. Microbiol. , e0211924 (2024), Abstract
Characterization of heart disease in mucopolysaccharidosis type II mice: A.M.V. Tavares, et al.; Cardiovasc. Pathol. 67, 107575 (2023), Abstract
Protective effects of L-carnitine on behavioral alterations and neuroinflammation in striatum of glutaryl-COA dehydrogenase deficient mice: G. Guerreiro, et al.; Arch. Biochem. Biophys. 709, 108970 (2021), Abstract
Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV: D. Pires, et al.; Front. Immunol. 18, 742822 (2021), Abstract
Cloning and characterization of a basic cysteine-like protease (cathepsin L1) expressed in the gut of larval Diaprepes abbreviatus L.(Coleoptera: Curculionidae): S. Ben-Mahmoud, et al.; J. Insect Physiol. 72, 1 (2015), Abstract
Expression of a Codon-Optimized Carica papaya Papain Sequence in the Methylotrophic Yeast Pichia pastoris: N. Werner, et al.; J. Microb. Biochem. Technol. 7, 1948 (2015), Application(s): In vitro activation and Z-FR-pNa hydrolysis assay, Full Text
Photometric or fluorometric assay of cathepsin B, L and H and papain using substrates with an aminotrifluoromethylcoumarin leaving group: J.R. Tchoupe, et al.; Biochim. Biophys. Acta 1076, 149 (1991), Abstract

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Z-Phe-Arg-pNA . hydrochloride

ALX-260-130

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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