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Z-Phe-Ala-FMK

BML-PI138

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Caspase inhibitor

Irreversible inhibitor of cathepsins B, L, and S, and likely cathepsin H, as well as cruzain and papain. Has been shown to inhibit effector, but not initator, caspases in vitro, and suppress some forms of apoptosis. Has been used in vivo.

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Product Details

Appearance	White solid
CAS	197855-65-5
Formulation	Lyophilized
MW	386.4
Peptide Content	≥95%
Purity	≥95% (HPLC)
Sequence	Benzyloxycarbonyl-Phe-Ala-fluoromethylketone
Solubility	Soluble in DMSO (10mM)

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The Zoonotic Helminth Parasite Fasciola hepatica: Virulence-Associated Cathepsin B and Cathepsin L Cysteine Peptidases Secreted by Infective Newly Excysted Juveniles: T. Barbour, et al.; Animals 11, 3495 (2021), Abstract