Z-LR-AMC

BML-P229

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Cathepsin substrate

Sensitive fluorogenic substrate for cathepsin K (K_m=8µM, k_cat/K_m=4 x 10 M^-1s^-1). This substrate is also cleaved by cathepsin B, F, L, L2/V, S. Z-LR-AMC is also cleaved by malaria parasite cysteine proteases falcipain-1, -2, -3, berghepain, and vivapain-2, -3. Ex.: 365nm, Em.: 440nm, although the following Ex/Em can also be used: 355,380/450,460. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

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Product Details

Alternative Name	Z-Leu-Arg-AMC, Cathepsin K substrate (fluorogenic)
Appearance	White to off-white solid.
Formulation	Lyophilized.
MW	578.7
Purity	≥97% (HPLC)
Sequence	Z-Leu-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
Solubility	Soluble in DMSO to at least 20mM.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach: de Wildt, B. W. M., Cuypers, L. A. B., et al.; Adv. Healthc. Mater. 12, e2301205 (2023), Abstract
Impact of Sr2+ and hypoxia on 3D triple cultures of primary human osteoblasts, osteocytes and osteoclasts: K. Wirsig, et al.; Eur. J. Cell Biol. 101, 151256 (2022), Abstract
The impact of culture variables on 3D humanin vitrobone remodeling; a design of experiments approach: de Wildt, B. W., Cuypers, L. A., et al.; bioRxiv , (2022)
A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells: D.M. Mellott, et al.; ACS Chem. Biol. 16, 642 (2021), Abstract — Full Text
Fluoride does not inhibit enamel protease activity: C.E. Tye, et al.; J. Dent. Res. 90, 489 (2011), Application(s): Use of Z-LR-AMC to measure cathepsin K activity, Abstract — Full Text
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin: M.A. Leissring, et al.; PLoS One 5, e10504 (2010), Application(s): Use of Z-LR-AMC to measure cathepsin B activity, Abstract — Full Text
A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2: A. Singh, et al.; PEDS 20, 171 (2007), Abstract — Full Text
Cysteine protease falcipain 1 in Plasmodium falciparum is biochemically distinct from its isozymes: S.L. Goh, et al.; Parasitol. Res. 97, 295 (2005), Abstract
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2: K.C. Pandey, et al.; J. Biol. Chem. 279, 3484 (2004), Abstract — Full Text
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax: B.-K. Na, et al.; Biochem. J. 378, 529 (2004), Abstract — Full Text

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Z-LR-AMC

BML-P229

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Handling & Storage

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