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Fluorogenic substrate for the peptidylglutamyl-peptide hydrolysing (caspase-like) activity of the proteasome which may be stimulated in the presence of Mg2+ ions and rapidly inactivated by N-acetylimidazole.
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Product Details
| Alternative Name |
Z-LLE-AMC, Proteasome substrate II (fluorogenic) |
|---|---|
| Appearance |
Lyophilized. Off white powder. |
| Formula |
C35H44N4O9 |
| MW |
664.75 Da |
| Purity |
≥95% (HPLC) |
| Sequence |
Z-LLE-AMC (AMC=7-Amino-4-methylcoumarin) |
| Solubility |
Soluble in dimethylformamide. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Blue Ice |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons: Gorgogietas, V., Weiss, A., et al.; Sci. Rep. 15, 29507 (2025), Abstract
- Morphological profiling in human dopaminergic neurons identifies mitochondrial uncoupling as a neuroprotective effect: Gorgogietas, V., Weiss, A., et al.; bioRxiv , (2024)
- Mitochondrial Dysfunction and Protein Homeostasis in Aging: Insights from a Premature-Aging Mouse Model: Ross, J. M., Olson, L., et al.; Biomolecules 14, (2024), Reactant(s): Mouse, Abstract
- The role of proteasome in muscle wasting of experimental arthritis: V.O.N. Teixeira, et al.; Adv. Rheumatol. 63, 14 (2023), Abstract
- Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects: A.T. Anastasiadi, et al.; Front. Physiol. 13, 907444 (2022), Abstract
- The role of Cycloastragenol at the intersection of Nrf-2/ARE, telomerase, and proteasome activity: Yılmaz, S., Bedir, E., et al.; bioRxiv , (2022), Reactant(s): Human
- The role of cycloastragenol at the intersection of NRF2/ARE, telomerase, and proteasome activity: Yılmaz, S., Bedir, E., et al.; Free Radic. Biol. Med. 188, 105 (2022), Reactant(s): Human, Abstract
- Approaches and Protocols to Analyze Autophagy and Its Role in Death of Apoptosis-Resistant Senescent Tumor Cells: Kochetkova, E. Y., Pospelov, V. A., et al.; Methods Mol. Biol. 2445, 139 (2022), Abstract
- Short-term exposure to an obesogenic diet causes dynamic dysregulation of proteasome-mediated protein degradation in the hypothalamus of female rats: T. McFadden, et al.; Nutr. Neurosci. 13, 1 (2022), Abstract
- Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring: V.L. Tzounakas, et al.; Redox Biol. 57, 102477 (2022), Abstract
- The molecular network of the proteasome machinery inhibition response is orchestrated by HSP70, revealing vulnerabilities in cancer cells: M. Oroń, et al.; Cell Rep. 40, 111428 (2022), Abstract
- Immobilized Antibodies on Mercaptophenylboronic Acid Monolayers for Dual-Strategy Detection of 20S Proteasome: M.M. Barsan, et al.; Sensors 21, 2702 (2021), Abstract — Full Text
- Targeting AML dependency on VCP-mediated DNA repair through a selective second-generation small molecule inhibitor: B. Roux, et al.; Sci. Transl. Med. 13, eabg1168 (2021), Abstract
- Red Blood Cell Proteasome in Beta-Thalassemia Trait: Topology of Activity and Networking in Blood Bank Conditions: A.T. Anastasiadi, et al.; Membranes 11, 716 (2021), Abstract
- Aromatic monophenols from cinnamon bark act as proteasome inhibitors by upregulating ER stress, suppressing FoxM1 expression, and inducing apoptosis in prostate cancer cells: S. Gopalakrishnan, et al.; Phytother. Res. 35, 5781 (2021), Abstract
- Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes: S. Gumeni, et al.; Cell Death Dis. 12, 41419 (2021), Abstract
- 20S proteasomes secreted by the malaria parasite promote its growth: E. Dekel, et al.; Nat. Commun. 12, 1172 (2021), Abstract — Full Text
- Comprehensive Analysis of Proteasomal Complexes in Mouse Brain Regions Detects ENO2 as a Potential Partner of the Proteasome in the Striatum: N. Esfahanian, et al.; Cell. Mol. Neurobiol. , (2021), Abstract
- A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway: K. Wenzel, et al.; Front. Physiol. 12, 614878 (2021), Abstract
- Amniotic Fluid Proteasome and Immunoproteasome in the Setting of Intra-Amniotic Infection, Inflammation, and Preterm Birth: C.A. Ware, et al.; Reprod Sci. 28, 2562 (2021), Abstract
- Reproductive Potential of Yeast Cells Depends on Overall Action of Interconnected Changes in Central Carbon Metabolism, Cellular Biosynthetic Capacity, and Proteostasis: R. Maslanka & R. Zadrag-Tecza; Int. J. Mol. Sci. 21, 7313 (2020), Abstract — Full Text
- Gender-specific changes in energy metabolism and protein degradation as major pathways affected in livers of mice treated with ibuprofen: S. Tiwari, et al.; Sci. Rep. 10, 3386 (2020), Abstract — Full Text
- Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects: Scott, M. R., Meador-Woodruff, J. H., et al.; Mol. Psychiatry 25, 776 (2020), Abstract
- Dysregulation of protein degradation in the hippocampus is associated with impaired spatial memory during the development of obesity: McFadden, T., Musaus, M., et al.; Behav. Brain Res. 393, 112787 (2020), Reactant(s): Rat, Abstract
- Cell cycle-dependent localization of the proteasome to chromatin: Y. Kito, et al.; Sci. Rep. 10, 5801 (2020), Abstract — Full Text
- Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules: K. Georgousaki, et al.; Molecules 25, 666 (2020), Application(s): Proteasome activity in human fibroblasts lysates., Abstract — Full Text
- Mass spectrometry-based absolute quantification of 20S proteasome status for controlled ex-vivo expansion of Human Adipose-derived Mesenchymal Stromal/Stem Cells: T. Menneteau, et al.; Mol. Cell. Proteomics 18, 744 (2019), Abstract
- Males and Females Differ in the Subcellular and Brain Region Dependent Regulation of Proteasome Activity by CaMKII and Protein Kinase A: R.K. Devulapalli, et al.; Neuroscience 418, 1 (2019), Abstract
- A lowered 26S proteasome activity correlates with mantle lymphoma cell lines resistance to genotoxic stress: K. Ben Younes, et al.; BMC Cancer 17, 538 (2017), Abstract — Full Text
- A leptospiral AAA+ chaperone-Ntn peptidase complex, HslUV, contributes to the intracellular survival of Leptospira interrogans in hosts and the transmission of leptospirosis: S.L. Dong, et al.; Emerg. Microbes Infect. 6, e105 (2017), Abstract — Full Text
- The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System: A.C.D. Fuchs, et al.; Structure 25, 834 (2017), Abstract — Full Text
- Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases: L. Lauinger, et al.; Nat. Chem. Biol. 13, 709 (2017), Abstract — Full Text
- Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy: J. Li, et al.; J. Mol. Cell. Cardiol. 102, 53 (2016), Abstract
- The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies: S. Bhattarai, et al.; J. Autoimmun. 75, 118 (2016), Application(s): Measurement of CT-L and CL proteasome activity, Abstract
- Pim1 inhibition as a novel therapeutic strategy for Alzheimer’s disease: R. Velazquez, et al.; Mol. Neurodegener. 11, 52 (2016), Application(s): Proteasome activity, brain homogenate, Abstract — Full Text
- Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation: W.H. Choi, et al.; Nat. Commun. 7, 10963 (2016), Application(s): Western blot, Abstract
- Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts: A.D. Sklirou, et al.; Redox Biol. 5, 205 (2015), Application(s): Fluorescent detection, Abstract
- FV-162 is a novel, orally bioavailable, irreversible proteasome inhibitor with improved pharmacokinetics displaying preclinical efficacy with continuous daily dosing: Z. Wang, et al.; Cell Death Dis. 6, e1815 (2015), Application(s): Proteasome activity assays, Abstract — Full Text
- The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells: M. Hamouda, et al.; Oncotarget 5, 6252 (2014), Application(s): Analysis of velcade resistant multiple myeloma human cells by WB, Assay, Abstract — Full Text
- Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Fluorogenic substrate for kinetics assay of 20S proteasome, Abstract — Full Text
- STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy: J.V. Ferreira, et al.; Autophagy 9, 1349 (2013), Abstract
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