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Z-IE(OMe)TD(OMe)-FMK

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Caspase and granzyme inhibitor

Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.

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Alternative Name	Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone)
Appearance	White to off-white solid.
Formula	C₃₀H₄₃FN₄O₁₁
MW	654.7
Purity	≥95% (TLC)
Sequence	Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
Solubility	Soluble in DMSO.
Technical Info / Product Notes	We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.

Use/Stability	As indicated on product label or CoA when stored as recommended. Store stock solutions in aliquots at -20°C.
Handling	Packaged under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract
Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC 277, 311 (2000), Abstract
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood 94, 291 (1999), Abstract — Full Text
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem. 273, 4345 (1998), Abstract — Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett. 425, 61 (1998), Abstract
Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry 37, 16934 (1998), Abstract

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