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Z-D(OMe)E(OMe)VD(OMe)-FMK

ALX-260-072

11 citations

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Inhibitor of caspase-3 and -7

Irreversible, cell permeable inhibitor of caspase-3 and -7.

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Product Details

Alternative Name	Caspase-3 inhibitor (fluoromethylketone), Caspase-7 inhibitor (fluoromethylketone)
Formula	C₃₀H₄₁FN₄O₁₂
Formulation	Lyophilized.
MW	668.7
Purity	≥95% (TLC)
Sequence	Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Solubility	Soluble in DMSO (20mM) or dimethyl formamide.
Technical Info / Product Notes	We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for 1 year after receipt when stored at -20°C.
Handling	Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Hip is a pro-survival substrate of granzyme B: Hostetter, D. R., Loeb, C. R., et al.; J. Biol. Chem. 282, 27865 (2007), Abstract
Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells: K. Hishikawa, et al.; Eur. J. Pharmacol. 392, 19 (2000), Abstract
Caspase-3-dependent and -independent degradation of 28 S ribosomal RNA may be involved in the inhibition of protein synthesis during apoptosis initiated by death receptor engagement: D. Nadano & T.A. Sato; J. Biol. Chem. 275, 13967 (2000), Abstract — Full Text
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32: D. Vaudry, et al.; PNAS 97, 13390 (2000), Abstract — Full Text
Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration: C. Liu, et al.; J. Neurosci. 19, 4778 (1999), Abstract — Full Text
Caspase-8 mediates caspase-3 activation and cytochrome c release during singlet oxygen-induced apoptosis of HL-60 cells: S. Zhuang, et al.; Exp. Cell Res. 250, 203 (1999), Abstract
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury: Y. Cheng, et al.; J. Clin. Invest. 101, 1992 (1998), Abstract
Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells: Y. Masuda, et al.; BBRC 234, 641 (1997), Abstract
CPP32/apopain is a key interleukin 1 β converting enzyme-like protease involved in Fas-mediated apoptosis: J. Schlegel, et al.; J. Biol. Chem. 271, 1841 (1996), Abstract — Full Text
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis: D.W. Nicholson; Nature Biotechnol. 14, 297 (1996), Abstract

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Z-D(OMe)E(OMe)VD(OMe)-FMK

ALX-260-072

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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