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Z-DEVD-FMK (Ready-to-Use)

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Inhibitor of caspase-3 and -7

Irreversible, cell permeable inhibitor of caspase-3 and -7.

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Alternative Name	Caspase-3 inhibitor (fluoromethylketone), Caspase-7 inhibitor (fluoromethylketone)
Formulation	Liquid. In DMSO.
MW	668.0
Purity	≥98% (HPLC)
Sequence	Z-Asp-Glu-Val-Asp-fluoromethylketone
Technical Info / Product Notes	We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Conjunctival epitheliopathy induced by topical exposure to bacterial peptidoglycan, muramyl dipeptide: M.P. Langford, et al.; Exp. Eye Res. 227, 109383 (2023), Abstract
IL-21R-STAT3 signalling initiates a differentiation program in uterine tissue-resident NK cells to support pregnancy: M. Han, et al.; Nat. Commun. 14, 7109 (2023), Abstract
Clostridioides difficile toxin B alone and with pro-inflammatory cytokines induces apoptosis in enteric glial cells by activating three different signalling pathways mediated by caspases, calpains and cathepsin B: K. Fettucciari, et al.; Cell. Mol. Life Sci. 79, 442 (2022), Abstract
Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling: L.E. Araya, et al.; ACS Chem. Biol. 16, 2280 (2021), Abstract
Coordination of receptor tyrosine kinase signaling and interfacial tension dynamics drive radial intercalation and tube elongation: N. Neumann, et al.; Dev. Cell 45, 67 (2018), Abstract — Full Text
Human thymus medullary epithelial cells promote regulatory T-cell generation by stimulating interleukin-2 production via ICOS ligand: Nazzal, D., Gradolatto, A., et al.; Cell Death Dis. 5, e1420 (2014), Reactant(s): Human, Abstract

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