Home Shop Z-Asp-2,6-dichlorobenzoyloxymethylketone

Z-Asp-2,6-dichlorobenzoyloxymethylketone

ALX-260-029

Datasheet
Manual
SDS
CofA

Already have an account?

Caspase inhibitor

Irreversible, cell permeable broad-spectrum caspase inhibitor.
Caspase-3 IC₅₀: 1,1µM
Caspase-6 IC₅₀: 4,1µM
Less effective on the inhibition of caspase-1- and 8-like activities.
Inhibits hypoxia-induced apoptosis in neuroblastoma cells.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	Caspase family inhibitor, Z-Asp-CH2-DCB, Z-L-Asp-a-[2,6-(dichlorobenzoyl)oxy]methane
Appearance	White to off-white powder.
CAS	153088-73-4
Formula	C₂₀H₁₇Cl₂NO₇
MW	454.3
Purity	≥98% (TLC)
Solubility	Soluble in methanol (50mg/ml) or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction: Y. Chandrashekhar, et al.; J. Am. Coll. Cardiol. 43, 295 (2004), Abstract
Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation: T. Krakauer; Clin. Diagn. Lab. Immunol. 11, 621 (2004), Abstract — Full Text
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension: L. Taraseviciene-Stewart; FASEB J. 15, 427 (2001), Abstract — Full Text
Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2′,3′,4′-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest: C. Gajate, et al.; Cancer Res. 60, 2651 (2000), Abstract — Full Text
Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000), Abstract
LPS-induced signals in activation of caspase-3-like protease, a key enzyme regulating apoptotic cell damage into a macrophage-like cell line, J774.1, in the presence of cycloheximide: H. Karahashi & F. Amano; J. Leukoc. Biol. 66, 689 (1999), Abstract — Full Text
Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells: U.K. Messmer et al.; Kidney Int. 55, 2322 (1999), Abstract — Full Text
Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria: R. Araya, et al.; FEBS Lett. 439, 168 (1998), Abstract
Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells: T. Mashima, et al.; BBRC 209, 907 (1995), Abstract
P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta- converting enzyme: R.E. Dolle, et al.; J. Med. Chem. 37, 563 (1994), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Z-Asp-2,6-dichlorobenzoyloxymethylketone

ALX-260-029

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project