Z-AAD-CMK

BML-P165

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Caspase inhibitor

Irreversible, cell-permeable inhibitor of granzyme B (ID₅₀=0.3 µM). Does not inhibit granzyme A. Inhibition of granzyme B with Z-AAD-CMK prevented caspase-3 activation in T cells.

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Product Details

Alternative Name	Granzyme B inhibitor
Appearance	White to off-white solid.
Formula	C₁₉H₂₄ClN₃O₇
Formulation	Lyophilized.
MW	441.9
Purity	≥95% (HPLC)
Sequence	Benzyloxycarbonyl-Ala-Ala-Asp-chloromethylketone
Solubility	Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml) or water (20mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition: M. Montalvo, et al.; Cell Death Dis. 15, 109 (2024), Abstract
Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer: M. Kim, et al.; PLoS One 13, e0198347 (2018), Abstract — Full Text
Th9 Cells Represent a Unique Subset of CD4+ T Cells Endowed with the Ability to Eradicate Advanced Tumors: Lu, Y., Wang, Q., et al.; Cancer Cell 33, 1048 (2018), Abstract
Granzyme B expression is enhanced in human monocytes by TLR8 agonists and contributes to antibody-dependent cellular cytotoxicity: S. Elavazhagan, et al.; J. Immunol. 194, 2786 (2015), Abstract — Full Text
IFN-γ stimulated human umbilical-tissue-derived cells potently suppress NK activation and resist NK-mediated cytotoxicity in vitro: C. Noone, et al.; Stem Cells Dev. 22, 3003 (2013), Abstract — Full Text
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation: J.J. Karrich, et al.; Blood. 121, 3103 (2013), Abstract — Full Text
Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-γ: C. Schürch, et al.; J. Exp. Med. 210, 605 (2013), Abstract — Full Text
Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts: S.A. Quezada, et al.; J. Exp. Med. 207, 637 (2010), Abstract — Full Text

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Z-AAD-CMK

BML-P165

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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