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(Z)-4-Hydroxytamoxifen

ALX-550-361

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Tamoxifen metabolite

Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.

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Product Details

Alternative Name	(Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
Appearance	White to off-white powder.
CAS	68047-06-3, 65213-48-1
Formula	C₂₆H₂₉NO₂
Identity	Determined by MS.
MW	387.5
Purity	≥98% (UHPLC)
Solubility	Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

GIT1 protects against breast cancer growth through negative regulation of Notch: Zhang, S., Miyakawa, A., et al.; Nat. Commun. 13, 1537 (2022), Abstract
Lytic Replication and Reactivation from B Cells Is Not Required for Establishing or Maintaining Gammaherpesvirus Latency In Vivo: Gupta, A., Owens, S. M., et al.; J. Virol. 96, e0069022 (2022), Abstract
Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis: L. Mayes-Hopfinger, et al.; Nat. Commun. 12, 4546 (2021), Abstract
Lytic Replication and Reactivation from B Cells Is Not Required for Maintaining Gammaherpesvirus Latency i>in vivo/i>: Gupta, A., Owens, S. M., et al.; bioRxiv , (2021)
Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection: Salinas, E., Gupta, A., et al.; PLoS Pathog. 14, e1006865 (2018), Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999), Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999), Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994), Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993), Abstract
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990), Abstract

Related Products

Tamoxifen . citrate

ALX-550-095

PKC inhibitor

25 citations

Alternative Name	(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-ethanamine . citrate
CAS	54965-24-1
Couple Type	Inhibitor
Purity	≥99% (Assay)

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(Z)-4-Hydroxytamoxifen

ALX-550-361

Product Details

Handling & Storage

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