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Sequence is from hamster polyoma virus middle T inclusive of Tyr324. This 11-residue phosphopeptide activates Src family members by binding with high affinity (Kd=3-6 nM for Src SH2) to their SH2 domains. The crystal structures of this peptide complexed to Src and Lck SH2 domains have been determined.
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RUO – Research Use Only |
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