YC-1

ALX-420-025

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Guanylyl cyclase activator

Nitric oxide (NO) independent, superoxide-sensitive stimulator of soluble guanylyl cyclase (sGC), EC₅₀=18.6μM. Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. Non-specific phosphodiesterase inhibitor. YC-1 inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.Binds to [³H]BW202W92.

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Product Details

Appearance	White to pale yellow powder.
CAS	170632-47-0
Couple Target	Guanylyl cyclase
Couple Type	Activator
Formula	C₁₉H₁₆N₂O₂
Identity	Identity determined by 1H-NMR.
MW	304.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO, methanol or dichloromethane.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selection, Analysis and Improvement of Anti-Angiogenesis Compounds Identified by an Anti-HIF-1α Screening and Validation System: C. Madu, et al.; J. Cancer 7, 1926 (2016), Application(s): Screening for anti-HIF-1α compounds and chemical modification of the lead compound G3, Abstract — Full Text
Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter: A. Salvi & T. Thanabalu; Biochem. Biophys. Rep. 9, 13 (2016), Abstract — Full Text
A Novel Drug Binding Site on Voltage-Gated Sodium Channels in Rat Brain: D. R. Riddall, et al.; Mol. Pharmacol. 69, 278 (2006), Abstract
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury: Duranski, M. R., Elrod, J. W., et al.; Am. J. Physiol. Heart Circ. Physiol. 291, H2980 (2006), Abstract
Soluble guanylyl cyclase activator YC-1 protects white matter axons from nitric oxide toxicity and metabolic stress, probably through Na(+) channel inhibition: G. Garthwaite, et al.; Mol. Pharmacol. 61, 97 (2002), Abstract
Generation and characterization of a stable soluble guanylate cyclase-overexpressing CHO cell line: E.M. Becker, et al.; Nitric Oxide 3, 55 (1999), Abstract
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum: K. Hebeiss & H. Kilbinger; Neuroscience 82, 623 (1998), Abstract
Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide: J.R. Stone & M.A. Marletta; Chem. Biol. 5, 255 (1998), Abstract
Mechanism of YC-1-induced activation of soluble guanylyl cyclase: A. Friebe & D. Koesling; Mol. Pharmacol. 53, 123 (1998), Abstract — Full Text
Inhibition of platelet adhesion to collagen by cGMP-elevating agents: C.C. Wu, et al.; BBRC 231, 412 (1997), Abstract

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YC-1

ALX-420-025

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Handling & Storage

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