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ROCK inhibitor
- Selective inhibitor of ROCK1 and ROC/2
- Highly potent inhibitor of smooth muscle contractions
- Media component used in the cryopreservation of stem cells
- Applications in cancer, cardiology, nephrology, neurology, and stem cell studies
- Highly cited
Y-27632 is a highly potent, cell permeable, selective and ATP competitive inhibitor of ROCK1 and ROCK2 (IC50=800nM). It acts as a potent inhibitor of agonist-induced Ca2+sensitization of myosin phosphorylation and smooth muscle contractions, blocks cell spreading, and suppresses RhoA-induced formation of stress fibers in hepatic stellate cells. Y-27632 significantly reduces the increase of inflammatory cytokines after reperfusion, preventing the development of acute renal failure. There are numerous application for this compound including: anti-nociceptive effect, cardioprotective effects, inhibition of superoxide production, mimicking effect of β-agonists on human cells, and suppression of tumor cell invasion.
There has been a growing interest in Y-27632 for use in stem cell self-renewal and reprogramming. It is known to increase the survival rate of human embryonic stem cells undergoing cryopreservation.
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Product Details
| Alternative Name |
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl |
|---|---|
| Appearance |
White to pale yellow powder. |
| CAS |
129830-38-2 |
| Couple Target |
ROCK |
| Couple Type |
Inhibitor |
| Formula |
C14H21N3O . 2HCl |
| Identity |
Identity determined by MS and NMR. |
| MW |
247.3 . 73.0 |
| Purity |
≥98% (HPLC (UV)) |
| Purity Detail |
Enantiomeric excess ≥96% |
| Solubility |
Soluble in DMSO (25mg/ml), methanol (25mg/ml), acetonitrile (<1mg/ml), dioxane (<1mg/ml), water (very soluble). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 1 month when stored at -20°C. |
|---|---|
| Handling |
Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Modelling inflammation-induced peripheral sensitization in a dish-more complex than expected?: Li, Y., Lock, A., et al.; Pain 166, 1662 (2025), Abstract
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- Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages: Pickering, S., Wilson, H. D., et al.; Nat. Commun. 15, 10764 (2024), Abstract
- Automated, High-Throughput Phenotypic Screening and Analysis Platform to Study Pre- and Post-Implantation Morphogenesis in Stem Cell-Derived Embryo-Like Structures: Shankar, V., van Blitterswijk, C., et al.; Adv. Sci. (Weinh.) 11, e2304987 (2024), Abstract
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- HSBP7 Rescue of a Titin Cardiomyopathy Identified by Morphological Profiling: Chopra, A., Pei, R., et al.; Research Square , (2024)
- Modelling inflammation-induced peripheral sensitization in a dish – more complex than expected?: Li, Y., Lock, A., et al.; bioRxiv , (2024)
- Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability: Smirnov, P., Przybilla, M., et al.; Nat. Commun. 15, 10183 (2024), Abstract
- Non-destructive transcriptomics via vesicular export: Armbrust, N., Geilenkeuser, J., et al.; bioRxiv , (2024)
- Crosstalk of moderate ROS and PARP‐1 contributes to sustainable proliferation of conditionally reprogrammed keratinocytes: L. Liu, et al.; J. Biochem. Mol. Toxicol. 37, e23262 (2023), Abstract
- Drug response profiles in patient-derived cancer cells across histological subtypes of ovarian cancer: real-time therapy tailoring for a patient with low-grade serous carcinoma: A. Murumägi, et al.; Br. J. Cancer 128, 678 (2023), Abstract
- ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma: N.W. Kam, et al.; J. Adv. Res. 56, 69 (2023), Abstract
- FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation: A. Colantoni, et al.; Int. J. Mol. Sci. 24, 3181 (2023), Abstract
- Preclinical investigation of patient derived cervical cancer organoids for precision medicine: H.S. Seol, et al.; J. Gynecol. Oncol. 34, e35 (2023), Abstract
- Revisiting and corrections to the annotated SRSF3 (SRp20) gene structure and RefSeq sequences from the human and mouse genomes: L. Yu, et al.; Cell Insight 2, 100089 (2023), Abstract
- The interaction of β-arrestin1 with talin1 driven by endothelin A receptor as a feature of α5β1 integrin activation in high-grade serous ovarian cancer: I. Masi, et al.; Cell Death Dis. 14, 73 (2023), Abstract
- β-adrenergic receptor regulates embryonic epithelial extensibility through actomyosin inhibition: Y. Mizoguchi, et al.; iScience 26, 108469 (2023), Abstract
- The drug efficacy testing in 3D cultures platform identifies effective drugs for ovarian cancer patients: E. Åkerlund, et al.; NPJ Precis. Oncol. 7, 111 (2023), Abstract
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- Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro: Doda, D., Alonso Jimenez, S., et al.; Development 150, (2023), Abstract
- Human pluripotent stem cells-derived inner ear organoids recapitulate otic developmentin vitro: Doda, D., Jimenez, S. A., et al.; bioRxiv , (2023)
- Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling: Chi, C., Knight, W. E., et al.; iScience 26, 107012 (2023), Abstract
- Biodegradable Poly-ε-Caprolactone Scaffolds with ECFCs and iMSCs for Tissue-Engineered Heart Valves: G. Lutter, et al.; Int. J. Mol. Sci. 23, 527 (2022), Abstract
- Analysis of the diagnosis of Japanese patients with primary ciliary dyskinesia using a conditional reprogramming culture: A. Kurokawa, et al.; Respir Investig. 60, 407 (2022), Abstract
- A novel renal perivascular mesenchymal cell subset gives rise to fibroblasts distinct from classic myofibroblasts: S. Minatoguchi, et al.; Sci. Rep. 12, 5389 (2022), Abstract
- Treating intrauterine adhesion using conditionally reprogrammed physiological endometrial epithelial cells: S. Xia, et al.; Stem Cell Res. Ther. 13, 178 (2022), Abstract
- High-content analysis of neuronal morphology in human iPSC-derived neurons: S. Lickfett, et al.; STAR Protoc. 3, 101567 (2022), Abstract — Full Text
- Response of TGF-β isoforms in epithelial-mesenchymal transition of enamel epithelial cells: Y. Miyakawa, et al.; Arch. Oral. Biol. 143, 105540 (2022), Abstract
- Actomyosin activity-dependent apical targeting of Rab11 vesicles reinforces apical constriction: W. Chen, et al.; J. Cell Biol. 221, e202103069 (2022), Abstract
- Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease: W. Wurst, et al.; Nat. Commun. 13, 4819 (2022), Abstract
- Epigenomic landscape study reveals molecular subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma: L.K.Y. Chow, et al.; EBioMedicine 86, 104357 (2022), Abstract
- Genomic characterization and therapeutic utilization of IL-13-responsive sequences in asthma: K.D. Koh, et al.; Cell Genom. 3, 100229 (2022), Abstract
- Long-Term Culture of Canine Ocular Cells That Maintain Canine Papillomaviruses: D. Zhou, et al.; Viruses 14, 2675 (2022), Abstract
- Transcriptome reprogramming of Epstein-Barr virus infected epithelial and B cells reveals distinct host-virus interaction profiles: N. Ma, et al.; Cell Death Dis. 13, 894 (2022), Abstract
- Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival: Villanueva, J. W., Kwong, L., et al.; BMC Genomics 23, 792 (2022), Abstract
- Detection of Circulating Gastrointestinal Cancer Cells in Conditionally Reprogrammed Cell Culture: C.S. Yang, et al.; In Vivo 35, 1515 (2021), Abstract
- PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification: S. Feloa, et al.; ACS Nano 15, 15992 (2021), Abstract
- Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome: G. Inak, et al.; Nat. Commun. 12, 1929 (2021), Abstract — Full Text
- Directed differentiation of human pluripotent stem cells into epidermal stem and progenitor cells: S. Ruiz-Torres, et al.; Mol. Biol. Rep. 48, 6213 (2021), Abstract — Full Text
- Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments: S.S. Talwelkar, et al.; Cell Rep. Med. 2, 100373 (2021), Abstract — Full Text
- Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders: A. Zink, et al.; Bio. Protoc. 11, e3939 (2021), Abstract — Full Text
- H3. 3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model: D. Haag, et al.; Cancer Cell 39, 407 (2021), Abstract
- Inherited DNA repair defects disrupt the structure and function of human skin: S. Ruiz-Torres, et al.; Cell Stem Cell 28, 424 (2021), Abstract — Full Text
- Non-invasive and high-throughput interrogation of exon-specific isoform expression: D.J.J. Truong, et al.; Nat. Cell Biol. 23, 652 (2021), Abstract — Full Text
- Patient-derived organotypic epithelial rafts model phenotypes in juvenile-onset recurrent respiratory papillomatosis: M.C. Bedard, et al.; Viruses 13, 68 (2021), Abstract — Full Text
- Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer: H.S. Lee, et al.; EBioMedicine 65, 103218 (2021), Abstract — Full Text
- RAB19 directs cortical remodeling and membrane growth for primary ciliogenesis: C.E. Jewett, et al.; Dev. Cell 56, 325 (2021), Abstract — Full Text
- Simplification of culture conditions and feeder-free expansion of bovine embryonic stem cells: D.A. Soto, et al.; Sci. Rep. 11, 11045 (2021), Abstract — Full Text
- Surfactant protein C mutation links postnatal type 2 cell dysfunction to adult disease: S. Sitaraman, et al.; JCI Insight 6, e142501 (2021), Abstract — Full Text
- Proteomic Analysis of Exosomes during Cardiogenic Differentiation of Human Pluripotent Stem Cells: P. Ashok & E.S. Tzanakakis; Cells 10, 2622 (2021), Abstract
- Deciphering cell signaling networks with massively multiplexed biosensor barcoding: J-M. Yang, et al.; Cell 184, 6193 (2021), Abstract
- Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer: R.R. Weng, et al.; Nat. Commun. 12, 2163 (2021), Abstract — Full Text
- Reprogramming of two induced pluripotent stem cell lines from a heterozygous GRIN2D developmental and epileptic encephalopathy (DEE) patient (BGUi011-A) and from a healthy family relative (BGUi012-A): T. Rabinski, et al.; Stem Cell Res. 51, 102178 (2021), Abstract
- Epithelial miR-141 regulates IL-13-induced airway mucus production: S. Siddiqui, et al.; JCI Insight 5, 139019 (2021), Abstract
- Reuse of Cell Culture Inserts for in vitro Human Primary Airway Epithelial Cell Studies: T. Kato, et al.; Am. J. Respir. Cell Mol. Biol. 64, 760 (2021), Abstract
- Biomechanical Strain Promotes the Differentiation of Murine Oogonial Stem Cells: J.A. MacDonald, et al.; Stem Cells Dev. 30, 749 (2021), Abstract
- Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene: K. E. Tan, et al.; Sci. Rep. 11, 14392 (2021), Abstract
- LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors: K.P. Eidell, et al.; J. Cell Sci. 36, 258602 (2021), Abstract
- Establishment of porcine and monkey colonic organoids for drug toxicity study: H. Li, et al.; Cell Regen. 10, 32 (2021), Abstract
- Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining: L. Yu, et al.; PLoS Pathog. 17, e1009812 (2021), Abstract
- Long-Term Maintenance of Viable Adult Rat Sertoli Cells Able to Establish Testis Barrier Components and Function in Response to Androgens: H. Kabbesh, et al.; Cells 10, 2495 (2021), Abstract
- Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells: S. Mishra, et al.; Cells 10, 1214 (2021), Abstract
- Probing TGF-β1-induced cytoskeletal rearrangement by fluorescent-labeled silica nanoparticle uptake assay: H.R. Shin, et al.; Biochem. Biophys. Rep. 28, 101137 (2021), Abstract
- Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles: Villanueva, J. W., Kwong, L., et al.; bioRxiv , (2021)
- Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability: Parra, R. G., Przybilla, M. J., et al.; bioRxiv , (2021)
- A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells: H.C. Yoo, et al.; Cell Metab. 31, 267 (2020), Abstract
- An excitable Ras/PI3K/ERK signaling network controls migration and oncogenic transformation in epithelial cells: H. Zhan, et al.; Dev. Cell. 54, 608 (2020), Abstract — Full Text
- Assessment of ethanol-induced toxicity on IPSC-derived human neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay: A. Zink, et al.; Front. Cell. Dev. Biol. 8, 590540 (2020), Abstract — Full Text
- Chromatin remodeling in bovine embryos indicates species-specific regulation of genome activation: M.M. Halstead, et al.; Nat. Commun. 11, 4654 (2020), Abstract — Full Text
- Efficient propagation of circulating tumor cells: a first step for probing tumor metastasis: J. Xiao, et al.; Cancers 12, 2784 (2020), Abstract — Full Text
- Forces during cellular uptake of viruses and nanoparticles at the ventral side: T. Wiegand, et al.; Nat. Commun. 11, 32 (2020), Abstract — Full Text
- Human bocavirus 1 infection of well‐differentiated human airway epithelium: Z. Yan, et al.; Curr. Protoc. Microbiol. 58, e107 (2020), Abstract — Full Text
- SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract: Y.J. Hou, et al.; Cell 182, 429 (2020), Abstract — Full Text
- A rapid quantification of invasive phenotype in head and neck squamous cell carcinoma: A novel 3D pillar array system: S. Y. Choi, et al.; Oral Oncol. 108, 104807 (2020), Application(s): Increase the viability of primary cancer cells., Abstract
- Murine neuroblastoma cell lines developed by conditional reprogramming preserve heterogeneous phenotypes observed in vivo: E. Krawczyk, et al.; Lab. Invest. 100, 38 (2020), Application(s): Culture and cryopreservation medium for neuroblastoma cell cultures, Abstract — Full Text
- Destabilization of β-catenin and RAS by Targeting the Wnt/β-catenin Pathway as a Potential Treatment for Triple-Negative Breast Cancer: W. Ryu, et al.; Exp. Mol. Med. 5, 832 (2020), Abstract — Full Text
- A PROTAC Peptide Induces Durable β-catenin Degradation and Suppresses Wnt-dependent Intestinal Cancer: H. Liao, et al.; Cell Discov. 6, 35 (2020), Abstract — Full Text
- Nanosecond pulsed current under plasma-producing conditions induces morphological alterations and stress fiber formation in human fibrosarcoma HT-1080 cells: C.H. Chang, et al.; Arch. Biochem. Biophys. 681, 108252 (2020), Abstract
- Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay: Zink, A., Conrad, J., et al.; bioRxiv , (2020)
- Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study: Urbaniak, A., Jousheghany, F., et al.; J. Biochem. Mol. Toxicol. 34, e22487 (2020), Abstract
- Single Cell Analysis Reveals Multi-faceted miR-375 Regulation of the Intestinal Crypt: Shanahan, M. T., Kanke, M., et al.; bioRxiv , (2020)
- Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings: J.R. Peters-Hall, et al.; FASEB J. 34, 386 (2019), Abstract — Full Text
- The response of phyllodes tumor of the breast to anticancer therapy: Anin vitroandex vivostudy: A. Urbaniak, et al.; Oncol. Lett. 18, 5097 (2019), Abstract — Full Text
- Dynamic Culture Substrates That Mimic the Topography of the Epidermal–Dermal Junction: A.L. Helling, et al.; Tissue Eng. Part A 25, 214 (2019), Abstract — Full Text
- The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells: H.L. Lung, et al.; Sci. Rep. 9, 12064 (2019), Abstract — Full Text
- TGFβ-induced cytoskeletal remodeling mediates elevation of cell stiffness and invasiveness in NSCLC: E. Gladilin, et al.; Sci. Rep. 9, 7667 (2019), Abstract
- Using a Three-Dimensional Collagen Matrix to Deliver Respiratory Progenitor Cells to Decellularized Trachea In Vivo: N.J.I. Hamilton, et al.; Tissue Eng. Part C Methods 25, 93 (2019), Abstract — Full Text
- Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner: Singh, A. P., Hung, Y. H., et al.; Cell. Mol. Gastroenterol. Hepatol. 9, 447 (2019), Abstract
- Gene Editing in 3D Cultured Nephron Progenitor Cell Lines: Li, Z., Araoka, T., et al.; Methods Mol. Biol. 1926, 151 (2019), Abstract
- mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma: Zhang, J., Jia, L., et al.; Oncogene 38, 4669 (2019), Abstract
- Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity: Hafner, M., Mills, C. E., et al.; Cell Chem. Biol. 26, 1067 (2019), Abstract
- Re-Defining Stem Cell-Cardiomyocyte Interactions: Focusing on the Paracrine Effector Approach: S. Mahapatra, et al.; J. Stem Cells Regen. Med. 14, 10 (2018), Abstract — Full Text
- Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling: C. Zhang, et al.; Cell Rep. 3, 598 (2018), Abstract — Full Text
- Generation of renewable mouse intestinal epithelial cell monolayers and organoids for functional analyses: E.C. Moorefield, et al.; BMC Cell Biol. 19, 15 (2018), Abstract — Full Text
- Development of new preclinical models to advance adrenocortical carcinoma research: K. Kiseljak-Vassiliades, et al.; Endocr. Relat. Cancer 2018, ERC-17-0447 (2018), Abstract
- Long-term expansion of primary equine keratinocytes that maintain the ability to differentiate into stratified epidermis: F. Alkhilaiwi, et al.; Stem Cell Res. Ther. 9, 181 (2018), Abstract — Full Text
- xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression: X. Ji, et al.; Oncogene 37, 5007 (2018), Abstract — Full Text
- Characterization of primary human mammary epithelial cells isolated and propagated by conditional reprogrammed cell culture: L. Jin, et al.; Oncotarget 9, 11503 (2018), Abstract — Full Text
- WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development: J. Richter, et al.; Genes 9, 66 (2018), Abstract
- Membrane Flow Drives an Adhesion-Independent Amoeboid Cell Migration Mode: O’Neill, P. R., Castillo-Badillo, J. A., et al.; Dev. Cell 46, 9 (2018), Abstract
- Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade: Kumar, B., Prasad, M., et al.; Cancer Res. 78, 5107 (2018), Abstract
- Substrate deformations induce directed keratinocyte migration: Zarkoob, H., Chinnathambi, S., et al.; J. R. Soc. Interface 15, (2018), Abstract
- Tropomyosin isoform Tpm2.1 regulates collective and amoeboid cell migration and cell aggregation in breast epithelial cells: H. Shin, et al.; Oncotarget 56, 95192 (2017), Abstract — Full Text
- TOP2A and EZH2 provide early detection of an aggressive prostate cancer subgroup: D.P. Labbé, et al.; Clin. Cancer Res. 22, 7072 (2017), Abstract — Full Text
- The full transcription map of mouse papillomavirus type 1 (MmuPV1) in mouse wart tissues: X.Y. Xue, et al.; PLoS Pathog. 11, e1006715 (2017), Abstract — Full Text
- Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling: S. Jeong, et al.; Oncotarget 20, 33544 (2017), Abstract — Full Text
- Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status: B.C. Peck, et al.; J. Biol. Chem. 7, 2586 (2017), Abstract — Full Text
- A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells: G. Walko, et al.; Nat. Commun. 8, 14744 (2017), Abstract — Full Text
- Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders: C. Lorenz, et al.; Cell Stem Cell 20, 659 (2017), Abstract
- Epithelial tension in the second heart field promotes mouse heart tube elongation: A. Francou, et al.; Nat. Commun. 8, 14770 (2017), Abstract — Full Text
- Potential antitumor activity and apoptosis induction of Glossostemon bruguieri root extract against hepatocellular carcinoma cells: M.S. Alwhibi, et al.; Evid. Based Complement Alternat. Med. 2017, 7218562 (2017), Application(s): Cell culture, Abstract — Full Text
- Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer: O.A. Timofeeva, et al.; Oncotarget 8, 22741 (2017), Application(s): Cell culture, Abstract — Full Text
- A cdk1 gradient guides surface contraction waves in oocytes: Bischof, J., Brand, C. A., et al.; Nat. Commun. 8, 849 (2017), Abstract
- Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt: Suprynowicz, F. A., Kamonjoh, C. M., et al.; PLoS One 12, e0180897 (2017), Abstract
- Myosin 2-Induced Mitotic Rounding Enables Columnar Epithelial Cells to Interpret Cortical Spindle Positioning Cues: Chanet, S., Sharan, R., et al.; Curr. Biol. 27, 3350 (2017), Abstract
- Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost: Roddy, G. W., Viker, K. B., et al.; Invest. Ophthalmol. Vis. Sci. 58, 2715 (2017), Abstract
- Generation of a C57BL/6 MYC-Driven Mouse Model and Cell Line of Prostate Cancer: L. Ellis, et al.; Prostate 13, 1192 (2016), Abstract — Full Text
- The impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness: M. Le Guen, et al.; Respir. Res. 17, 151 (2016), Abstract — Full Text
- A comparison of strategies for immortalizing mouse embryonic fibroblasts: M.M. St. Amad, et al.; J. Biol. Methods 3, e41 (2016), Application(s): Immortalization via Rock inhibitor supplementation, Full Text
- Caffeine Suppresses the Progression of Human Glioblastoma via Cathepsin B and MAPK Signaling Pathway: Y.C. Cheng, et al.; J. Nutr. Biochem. 33, 63 (2016), Application(s): Cell culture, Abstract
- Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure: E.W. Kuijk, et al.; Sci. Rep. 6, 22154 (2016), Application(s): Rat liver stem cell isolation and culture, Abstract — Full Text
- Down-regulation of 14-3-3 Zeta Inhibits TGF-β1-Induced Actomyosin Contraction in Human Trabecular Meshwork Cells Through RhoA Signaling Pathway: Y. Ye, et al.; Invest. Ophthalmol. Vis. Sci. 57, 719 (2016), Application(s): Cell culture, Abstract — Full Text
- Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism: J. Koh, et al.; J. Cell Mol. Med. 20, 351 (2016), Application(s): Cell culture, Abstract — Full Text
- Endothelin A receptor drives invadopodia function and cell motility through the β-arrestin/PDZ-RhoGEF pathway in ovarian carcinoma: E. Semprucci, et al.; Oncogene 35, 3432 (2016), Application(s): Cell culture , Abstract
- Functional transcriptomics in diverse intestinal epithelial cell types reveals robust gut microbial sensitivity of microRNAs in intestinal stem cells: Peck, B. C. E., Mah, A. T., et al.; bioRxiv , (2016)
- Rho-associated protein kinase regulates subcellular localisation of Angiomotin and Hippo-signalling during preimplantation mouse embryo development: Mihajlovic, A. I., Bruce, A. W., et al.; Reprod. Biomed. Online 33, 381 (2016), Abstract
- Time series modeling of live-cell shape dynamics for image-based phenotypic profiling: Gordonov, S., Hwang, M. K., et al.; Integr. Biol. (Camb.) 8, 73 (2016), Abstract
- High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling: Y. Zhao, et al.; Nat. Commun. 6, 8243 (2015), Application(s): Cell Culture, Abstract — Full Text
- Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells: W. Yang, et al.; PLoS One 10, e0134995 (2015), Application(s): Cell culture, Abstract — Full Text
- Vaginal innate immune mediators are modulated by a water extract of Houttuynia cordata Thunb: S. Satthakarn, et al.; BMC Complement. Altern. Med. 15, 183 (2015), Application(s): Cell Culture, Abstract — Full Text
- The effect of ROCK on TNF-α-induced CXCL8 secretion by intestinal epithelial cell lines is mediated through MKK4 and JNK signaling: A.C. Perey, et al.; Cell Immunol. 293, 80 (2015), Application(s): Cell Culture, Abstract
- Mucosal effects of tenofovir 1% gel: Hladik, F., Burgener, A., et al.; Elife 4, (2015), Abstract
- The connexin 43/ZO-1 complex regulates cerebral endothelial F-actin architecture and migration: Chen, C. H., Mayo, J. N., et al.; Am. J. Physiol. Cell Physiol. 309, C600 (2015), Abstract
- Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells: C.B. Pollock, et al.; Oncotarget 5, 1683 (2014), Application(s): Cell Culture, Abstract — Full Text
- Caffeine inhibits migration in glioma cells through the ROCK-FAK pathway: Chen, Y., Chou, W. C., et al.; Cell. Physiol. Biochem. 33, 1888 (2014), Abstract
- Human cytomegalovirus pUL37x1-induced calcium flux activates PKCα, inducing altered cell shape and accumulation of cytoplasmic vesicles: Sharon-Friling, R., Shenk, T., et al.; PNAS 111, E1140 (2014), Abstract
- Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment: J. Shi, et al.; Cell Death Dis. 4, e483 (2013), Abstract — Full Text
- Dissecting the roles of ROCK isoforms in stress-induced cell detachment: J. Shi, et al.; Cell Cycle 12, 1492 (2013), Abstract
- LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure: Gray, J. D., Kholmanskikh, S., et al.; Hum. Mol. Genet. 22, 4267 (2013), Abstract
- ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells: X. Liu, et al.; Am. J. Pathol. 180, 599,607 (2012), Abstract
- Use of reprogrammed cells to identify therapy for respiratory papillomatosis: H. Yuan, et al.; N. Engl. J. Med. 367, 1220 (2012), Abstract
- Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells: F.A. Suprynowicz, et al.; PNAS 109, 20035 (2012), Abstract
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