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X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). XBP-1 mRNA is spliced by IRE1p under ER stress, resulting in a 371 amino acid protein (XBP-1s) which is translocated to the nucleus where it binds to the regulatory elements of downstream genes. XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones grp78 and grp94.
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Western blot analysis of XBP-1S mAb (8F6.11) (Prod. No. ENZ-ABS255): Lane 1: MW markers, Lane 2: mock-transfected CHO cell, Lane 3: XBP-1S (spliced isoform)-transfected CHO cell. The observed molecular weight of XBP-1S is ~60 kDa (calculated MW: 40 kDa).
| Regulatory Status |
RUO – Research Use Only |
|---|
Related Products
| Application | ELISA, IHC, WB |
|---|---|
| Host | Goat |
| Species Reactivity | Rabbit |