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Xanthorrhizol

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Antibacterial and anti-inflammatory

Antibacterial and anti-inflammatory compound. Apoptosis inducer.

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Appearance	Colorless to light yellow oil.
CAS	30199-26-9
Formula	C₁₅H₂₂O
Identity	Identity determined by 1H-NMR, 13C-NMR and MS.
MW	218.3
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO or 100% ethanol.
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells: T. Handayani, et al.; Anticancer Res. 27, 965 (2007), Abstract
Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-kappa B: W.Y. Chung, et al.; Carcinogenesis 28, 1224 (2007), Abstract
Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells: N. Ismail, et al.; Anticancer Res. 25, 2221 (2005), Abstract
Xanthorrhizol: a potential antibacterial agent from Curcuma xanthorrhiza against Streptococcus mutans: J.K. Hwang, et al.; Planta Med. 66, 196 (2000), Abstract
Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from Cachani complex plants upon the contractile activity of uterine smooth muscle: H. Ponce-Monter, et al.; Phytother. Res. 13, 202 (1999), Abstract

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