Home Shop Xanthohumol

Xanthohumol

ALX-350-280

Datasheet
Manual
SDS
CofA

Already have an account?

DGAT inhibitor

Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT). Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Appearance	Yellow to orange powder.
CAS	569-83-5, 6754-58-1
Couple Target	Cytochrome P450, DGAT, DNA polymerase
Couple Type	Inhibitor
Formula	C₂₁H₂₂O₅
Identity	Identity determined by NMR.
MW	354.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml), methanol (10mg/ml) or 100% ethanol; soluble in aqueous buffers up to 20μM.
Source	Isolated from hops (Humulus lupulus).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH 7.5) systems.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Depigmenting effect of Xanthohumol from hop extract in MNT-1 human melanoma cells and normal human melanocytes: S. Goenka & S.R. Simon; Biochem. Biophys. Rep. 26, 100955 (2021), Abstract — Full Text
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Prostate Cancer Cells after Treatment with Xanthohumol – A Natural Compound Present in Humulus lupulus L.: M. Klosek, et al.; Int. J. Mol. Sci. 17, e837 (2016), Application(s): Cytotoxicity assay and detection of apoptotic cell death by flow cytometry, Abstract — Full Text
Anticancer agent xanthohumol inhibits IL-2 induced signaling pathways involved in T cell proliferation: Liu, Y., Gao, X., et al.; J. Exp. Ther. Oncol. 10, 1 (2012), Abstract
Targeting death receptor TRAIL-R2 by chalcones for TRAIL-induced apoptosis in cancer cells: Szliszka, E., Jaworska, D., et al.; Int. J. Mol. Sci. 13, 15343 (2012), Abstract
Immunomodulatory activity of xanthohumol: inhibition of T cell proliferation, cell-mediated cytotoxicity and Th1 cytokine production through suppression of NF-kappaB: Gao, X., Deeb, D., et al.; Immunopharmacol. Immunotoxicol. 31, 477 (2009), Abstract
Endocrine Disrupting Compounds (EDCs): Disrupting Human Endocrine Physiology and the Intricate Reproductive Balance: S.A. Sidiropoulos; UTMJ 85, 76 (2008), Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007), Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review), Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002), Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000), Abstract

Last modified: May 29, 2024

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Xanthohumol

ALX-350-280

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project