WY-14643

BML-GR200

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PPAR ligand

WY-14643 is a potent and widely used peroxisome proliferator activator receptor (PPAR) activator. It has been shown to be selective for PPARα.

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Product Details

Alternative Name	Pirinixic acid
Appearance	White to off-white solid.
CAS	50892-23-4
Couple Target	PPAR
Couple Type	Ligand
Formula	C₁₄H₁₄ClN₃O₂S
Identity	Determined by NMR.
MW	323.8
MeltingPoint	155-157°C
Purity	≥97% (HPLC)
RTECS	AG2915000
Solubility	Soluble in ethyl acetate or dilute base or slightly soluble in alcohol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia: H. Li, et al.; Exp. Neurol. 347, 113871 (2021), Abstract
Natural helix 9 mutants of PPARγ differently affect its transcriptional activity: M.F. Brokekema, et al.; Mol. Metab. 20, 115 (2019), Abstract
CRY1/2 Selectively Repress PPARd and Limit Exercise Capacity: S.D. Jordan, et al.; Cell Metab. 26, 243 (2017), Abstract — Full Text
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology: I.T. Bijsmans, et al.; Biochim. Biophys. Acta 1863, 687 (2016), Abstract
PPAR alpha Activation Reduces Hepatic CEACAM1 Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition: S.K. Ramakrishnan, et al.; J. Biol. Chem. 291, 8121 (2016), Application(s): Ingested by mice, Abstract — Full Text
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain: B.N. Okine, et al.; Scand. J. Pain. 9, 42 (2015), Application(s): Intraperitoneal injection to rat, Abstract
Use of fluorescence microscopy to probe intracellular lipolysis: Mottillo, E. P., Paul, G. M., et al.; Methods Enzymol. 538, 263 (2014), Abstract
A metabolic prosurvival role for PML in breast cancer: Carracedo, A., Weiss, D., et al.; J. Clin. Invest. 122, 3088 (2012), Abstract
Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis: Zak, Z., Gelebart, P., et al.; Leukemia 24, 1476 (2010), Abstract
Peroxisome proliferator-activated receptors: structures and function: J.D. Tugwood, et al.; Ann. N. Y. Acad. Sci. 804, 252 (1996), Abstract

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WY-14643

BML-GR200

Product Details

Handling & Storage

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