WS6

• GMP format available

WS6 is a small-molecule inhibitor of the IKB kinase pathway and ErbB3-binding protein 1 (EBP1), also known as proliferation-associated protein 2G4 (PA2G4), an RNA-binding protein involved in growth regulation.

Key features and applications include:

• Diabetes Research: WS6 is primarily used to study β cell proliferation, which is crucial for developing treatments for diabetes. It has been shown to increase β cell mass and normalize blood glucose levels in diabetic mouse models.
• Endocrinology and Metabolism: Researchers use WS6 to explore its effects on both α and β cell proliferation in human pancreatic islets, making it valuable for studies on endocrine function and metabolic diseases.
• Cell Proliferation Studies: WS6 is employed to investigate the mechanisms of cell proliferation, particularly through the IKB kinase pathway and ErbB3-binding protein 1 (EBP1).

Relevant disease states include:

• Type 1 Diabetes: WS6’s ability to promote β cell growth makes it relevant for research into potential therapies for Type 1 diabetes, where β cell loss is a primary concern.</li>
• Metabolic Disorders: Its role in enhancing pancreatic cell proliferation is also significant for studying various metabolic disorders that involve pancreatic dysfunction.